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    Glossary Interleukins

    proteins that help cells communicate in the immune system

    Interleukins are a group of proteins that play a crucial role in the immune system by facilitating communication between cells. They help regulate inflammation, immune responses, and the development of white blood cells. For example, certain interleukins can promote the growth of T-cells, which are essential for fighting infections, while others can trigger inflammation to help the body respond to injury or infection.

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    1. Interleukin 6: insights to its function in skin by overexpression in transgenic mice. Proceedings of the National Academy of Sciences · 1992 · 221 citations
    2. Dermatologic Changes Associated With Interleukin 2 Administration JAMA · 1987 · 123 citations
    3. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    4. The many faces of interleukin-17 in inflammatory skin diseases 2016 · 77 citations
    5. WNT5A drives interleukin-6-dependent epithelial–mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis Burns & Trauma · 2022 · 56 citations
    6. Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009 · 53 citations
    7. The association between Interleukin (IL)-4 gene intron 3 VNTR polymorphism and alopecia areata (AA) in Turkish population Gene · 2013 · 42 citations
    8. Testosterone stimulates proliferation and inhibits interleukin‐6 production of normal and hereditary gingival fibromatosis fibroblasts Oral Microbiology and Immunology · 2002 · 39 citations
    9. Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture Journal of interferon & cytokine research · 1997 · 38 citations
    10. Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages Annals of the Rheumatic Diseases · 2014 · 36 citations
    11. Interleukin-25-Mediated-IL-17RB Upregulation Promotes Cutaneous Wound Healing in Diabetic Mice by Improving Endothelial Cell Functions Frontiers in Immunology · 2022 · 34 citations
    12. Interleukin-1β-Induced Inhibition of Hair Growth In Vitro Is Mediated by Cyclic AMP Journal of Investigative Dermatology · 1997 · 33 citations
    13. Interleukin-10-deficient Mice Are Less Susceptible to the Induction of Alopecia Areata Journal of Investigative Dermatology · 2002 · 31 citations
    14. Recurrence of Pemphigus Vulgaris Associated With Interleukin 2 Therapy Archives of Dermatology · 1994 · 25 citations
    15. Association Between Interleukin 18 Polymorphisms and Alopecia Areata in Koreans Journal of Interferon & Cytokine Research · 2014 · 22 citations
    16. Alopecia Diffusa while Using Interleukin-17 Inhibitors against Psoriasis Vulgaris Case Reports in Dermatology · 2019 · 20 citations
    17. Minoxidil downregulates Interleukin-1 alpha gene expression in HaCaT cells International Journal of Trichology · 2018 · 16 citations
    18. Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis Journal of Investigative Dermatology · 2016 · 16 citations
    19. Evaluation of the level of serum Interleukins (IL-2, IL-4, IL-15 andIL-17) and its relationship with disease severity in patients with alopecia areata 2021 · 14 citations
    20. Serum level of interleukin-15 in active alopecia areata patients and its relation to age, sex, and disease severity Advances in Dermatology and Allergology · 2020 · 14 citations
    21. Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by the Increase of Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps Mediators of inflammation · 2019 · 14 citations
    22. Influence of interleukin‐1α on androgen receptor expression and cytokine secretion by cultured human dermal papilla cells Experimental Dermatology · 2006 · 14 citations
    23. Genetic analysis of interleukin 18 gene polymorphisms in alopecia areata Journal of Clinical Laboratory Analysis · 2018 · 12 citations
    24. Interleukin 6 and STAT3 regulate p63 isoform expression in keratinocytes during regeneration Experimental Dermatology · 2015 · 11 citations
    25. A functional polymorphism in interleukin-1α (IL1A) gene is associated with risk of alopecia areata in Chinese populations Gene · 2013 · 11 citations
    26. Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice Inflammation and Regeneration · 2023 · 7 citations
    27. <i>Trichophyton tonsurans</i>‐induced kerion celsi with decreased defensin expression and paradoxically increased interleukin‐17A production The Journal of Dermatology · 2019 · 7 citations
    28. Interleukin-15 and Tumor Necrosis Factor-α in Iraqi Patients with Alopecia Areata Dermatology Research and Practice · 2023 · 6 citations
    29. To evaluate the role of interleukin-6 in alopecia areata Journal of the Pakistan Medical Association · 2024 · 5 citations
    30. RETRACTED: Interleukin‐33 links asthma to alopecia areata: Mendelian randomization and mediation analysis Skin Research and Technology · 2024 · 4 citations