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    Did you mean Interleukin-15?
    Glossary Interleukin-15

    protein that stimulates immune cells, including NK and T cells

    Interleukin-15 (IL-15) is a protein that plays a crucial role in the immune system by promoting the growth and activity of certain white blood cells, including natural killer (NK) cells and T cells. It is involved in immune responses and has been studied for its potential role in conditions like alopecia areata, where it may contribute to the autoimmune attack on hair follicles.

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    1. Serum level of interleukin-15 in active alopecia areata patients and its relation to age, sex, and disease severity Advances in Dermatology and Allergology · 2020 · 14 citations
    2. Evaluation of the level of serum Interleukins (IL-2, IL-4, IL-15 andIL-17) and its relationship with disease severity in patients with alopecia areata 2021 · 14 citations
    3. Interleukin-15 and Tumor Necrosis Factor-α in Iraqi Patients with Alopecia Areata Dermatology Research and Practice · 2023 · 6 citations
    4. Interleukin-15 is a hair follicle immune privilege guardian Journal of Autoimmunity · 2024 · 1 citations
    5. Elevated serum heat shock protein-70 and interleukin-15: prognostic biomarkers correlating with clinical severity and diagnostic efficacy in active alopecia areata Journal of the Egyptian Womenʼs Dermatologic Society · 2026
    6. Interleukin 15 Gene Polymorphism in patients with Alopecia Areata The Egyptian Journal of Hospital Medicine · 2022
    7. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    8. Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice Inflammation and Regeneration · 2023 · 7 citations
    9. Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1β-mediated signaling Heliyon · 2017 · 3 citations
    10. Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma Nature medicine · 2015 · 245 citations
    11. Increase in IL-15 levels in patients with alopecia areata Journal of Education Health and Sport · 2020 · 2 citations
    12. IL-15 in alopecia areata: the immune tolerance mechanistic insights and translational perspectives Frontiers in Medicine · 2026
    13. Secretome of Hypoxic Mesenchymal Stem Cells Improves Fluconazole-Induced Alopecia in Rats via Immunoregulatory Modulation of IL-15 and IFN-γ Biosaintifika Journal of Biology & Biology Education · 2024
    14. 013 IL-15/IL-15Rα signaling is a guardian of human hair follicle immune privilege and promotes hair growth 2022
    15. 056 IL-15 prolongs hair growth and operates as a guardian of human hair follicle immune privilege Journal of Investigative Dermatology · 2022
    16. 033 IL-15 is an unexpected guardian of hair follicle immune privilege and promotes human hair growth ex vivo Journal of Investigative Dermatology · 2021
    17. Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration Cell Reports · 2023 · 44 citations
    18. Interleukins gene polymorphism in alopecia areata patients: a systematic review 2025 · 1 citations
    19. Myrtus communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing Dove Medical Press (Taylor and Francis Group) · 2026
    20. Abstract 152 Plastic and Reconstructive Surgery · 2015
    21. Interleukin-25-Mediated-IL-17RB Upregulation Promotes Cutaneous Wound Healing in Diabetic Mice by Improving Endothelial Cell Functions Frontiers in Immunology · 2022 · 34 citations
    22. The Functional Relevance of the Type 1 Cytokines IFN-γ and IL-2 in Alopecia Areata of C3H/HeJ Mice Journal of Investigative Dermatology Symposium Proceedings · 2005 · 20 citations
    23. Alopecia areata: a review of disease pathogenesis 2018 · 191 citations
    24. An integrated model of alopecia areata biomarkers highlights both TH1 and TH2 upregulation Journal of Allergy and Clinical Immunology · 2018 · 58 citations
    25. Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders Frontiers in Immunology · 2020 · 20 citations
    26. Causal relationship between inflammatory cytokines and polycystic ovary syndrome: a bidirectional mendelian randomization study Journal of Ovarian Research · 2024 · 12 citations
    27. Hair regrowth in alopecia areata and re‐pigmentation in vitiligo in response to treatment: Commonalities and differences Journal of the European Academy of Dermatology and Venereology · 2024 · 11 citations
    28. What is behind the ‘swarm of bees’ in alopecia areata British Journal of Dermatology · 2018 · 7 citations
    29. Sudden improvement of alopecia universalis and psoriatic arthritis while receiving upadacitinib: a case-based review Reumatismo · 2024 · 5 citations
    30. Inflammatory loops in the epithelial–immune microenvironment of the skin and skin appendages in chronic inflammatory diseases Frontiers in immunology · 2023 · 3 citations