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    Glossary Interferons

    Interferons are a group of signaling proteins produced by the immune system in response to viral infections and other stimuli. They play a crucial role in regulating immune responses and have been studied for their potential effects on hair biology, particularly in conditions like alopecia areata, where they may help modulate inflammation and promote hair regrowth. Key distinguishing characteristics of interferons include their ability to enhance the activity of immune cells and their role in inhibiting viral replication, which can indirectly influence hair follicle health and cycling.

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    1. Interferon alfa-2a in the treatment of cutaneous T cell lymphoma Journal of The American Academy of Dermatology · 1989 · 209 citations
    2. Interferon in the treatment of cutaneous T-cell lymphoma Dermatologic Therapy · 2003 · 107 citations
    3. Reversible Alopecia Universalis During Treatment with PEG-Interferon and Ribavirin for Chronic Hepatitis C Journal of Chemotherapy · 2005 · 27 citations
    4. INTERFERONS IN DERMATOLOGY Dermatologic Clinics · 1998 · 22 citations
    5. Partial regrowth of scalp hair in a patient treated with extracorporeal pholtochemotherapy and interferon ? 2a Journal of The European Academy of Dermatology and Venereology · 1998 · 2 citations
    6. Intrinsic Modulators of Hair Growth: Roles of Growth Factors, Cytokines, Chemokines, and Interferons International Journal of Trichology · 2025
    7. Effect of diode pumping solid state laser with wavelength 589 nm on gene expression of interlukine-2 and interferon-gamma Lowercase in human T-lymphocytes Journal of the Pakistan Medical Association · 2024
    8. Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment Gut · 2013 · 278 citations
    9. The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1 New England Journal of Medicine · 2024 · 71 citations
    10. A Review of Adverse Cutaneous Drug Reactions Resulting from the Use of Interferon and Ribavirin Canadian Journal of Gastroenterology · 2009 · 64 citations
    11. Concomitant Vitiligo and Psoriasis in a Patient Treated with Interferon Alfa‐2a for Chronic Hepatitis B Infection Pediatric Dermatology · 2004 · 60 citations
    12. Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege Experimental Dermatology · 2011 · 47 citations
    13. Reversible alopecia universalis secondary to PEG-interferon ??-2b and ribavirin combination therapy in a patient with chronic hepatitis C virus infection European Journal of Gastroenterology & Hepatology · 2007 · 41 citations
    14. High dose interferon treatment in chronic hepatitis C. Gut · 1993 · 36 citations
    15. Alopecia areata during Interferon Alpha-2b/Ribavirin Therapy Dermatology · 2002 · 35 citations
    16. Lichen planus and other cutaneous manifestations in chronic hepatitis C: pre- and post-interferon-based treatment prevalence vary in a cohort of patients from low hepatitis C virus endemic area Journal of the European Academy of Dermatology and Venereology · 2008 · 34 citations
    17. Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin PLOS ONE · 2013 · 24 citations
    18. Selective Expression of Chemokine Monokine Induced by Interferon-γ in Alopecia Areata Journal of Investigative Dermatology · 2003 · 20 citations
    19. Vogt-Koyanagi-Harada disease occurring during pegylated interferon-α2b and ribavirin combination therapy for chronic hepatitis C The Korean Journal of Hepatology · 2011 · 17 citations
    20. Treatment of Alopecia Areata with Anti-Interferon-γ Antibodies Journal of Investigative Dermatology Symposium Proceedings · 2005 · 16 citations
    21. Segmental Vitiligo and Hair Curling After Interferon α and Ribavirin Treatment for Hepatitis C Skinmed · 2006 · 14 citations
    22. Failure to induce alopecia areata in C3H/HeJ mice with exogenous interferon gamma Journal of experimental animal science · 2006 · 13 citations
    23. Interferon β Secreted from Human Hair Dermal Papilla Cells Inhibits the Growth of Outer Root Sheath Cells Cultured in Vitro Biochemical and biophysical research communications · 2002 · 13 citations
    24. Predictive factors for adverse dermatological events during pegylated/interferon alpha and ribavirin treatment for hepatitis C Journal of Clinical Virology · 2014 · 11 citations
    25. Exacerbation of alopecia areata during pegylated interferon alpha-2b and ribavirin therapy, possibly due to the collapse of hair follicle immune privilege European Journal of Dermatology · 2014 · 10 citations
    26. Cutaneous ulcers due to interferon seem not to be related to the dosage Journal of the European Academy of Dermatology and Venereology · 1999 · 9 citations
    27. Alopecia universalis as a side effect of pegylated interferon α-ribavirin combination therapy for hepatitis C: a rare case report Journal of Chemotherapy · 2016 · 6 citations
    28. Alopecia universalis following interferon alfa-2b and ribavirin treatment for hepatitis C. PubMed · 2007 · 4 citations
    29. Performance of an interferon-γ release assay-based test for cell-mediated immunity to SARS-CoV-2 Frontiers in Immunology · 2023 · 3 citations
    30. Alopecia universalis after discontinuation of pegylated interferon and ribavirin combination therapy for hepatitis C: a case report Annals of Hepatology · 2014 · 3 citations