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    Did you mean Hyperkeratosis?
    Glossary Hyperkeratosis

    excessive thickening of skin's outer layer due to keratin

    Hyperkeratosis is a condition where the outer layer of the skin, known as the stratum corneum, becomes excessively thick due to an overproduction of keratin. This can result in rough, scaly patches on the skin and is often seen in conditions like psoriasis or eczema. For professionals, it is important to note that hyperkeratosis can be a response to chronic irritation or inflammation and may require targeted treatments to manage the underlying cause.

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    Research 30 of 1000+

    1. Follicular cysts and hyperkeratoses in early mycosis fungoides International Journal of Dermatology · 1998 · 3 citations
    2. Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation 2014 · 32 citations
    3. [Dermatophytic disease: exuberant hyperkeratosis with cutaneous horns]. PubMed · 1998 · 6 citations
    4. A combination of low-dose systemic etretinate and topical calcipotriol/betamethasone dipropionate treatment for hyperkeratosis and itching in Olmsted syndrome associated with a TRPV3 mutation Journal of dermatological science · 2017 · 5 citations
    5. Resolution of the plantar hyperkeratosis of pachyonychia congenita during chemotherapy for Ewing sarcoma British Journal of Dermatology · 2013 · 2 citations
    6. 738 Cryo-EM and molecular dynamics of TRPV3 channel in activated state reveal structural features implicated in severe itch and hyperkeratosis 2023
    7. Systematized Epidermal Nevus with Epidermolytic Hyperkeratosis Improving with Topical Calcipotriol/Betametasone Dipropionate Combination Ointment Pediatric Dermatology · 2012 · 12 citations
    8. Intracorneal vacuoles in skin diseases with parakeratotic hyperkeratosis in the dog: a retrospective light‐microscopy study of 111 cases (1973–2000) Veterinary Dermatology · 2002 · 7 citations
    9. Unilateral nevoid hyperkeratosis of the nipple and areola in a Saudi female Our Dermatology Online · 2018 · 2 citations
    10. <i>GJB6</i> missense variant in a Labrador Retriever with paw pad hyperkeratosis Animal Genetics · 2026
    11. Actinic Hyperkeratosis Treated with Retinol Combined with a Polylysine Biovector: A Case Report 2025
    12. Actinic Hyperkeratosis Treated with Retinol Combined with A Polylysine Biovector: A Case Report ARC Journal of Clinical Case Reports · 2025
    13. A Rare Case of Orthokeratotic Hyperkeratosis in a Kid Induced by Malassezial Dermatitis The Indian Veterinary Journal · 2024
    14. Multiple minute digitate hyperkeratosis Journal of the European Academy of Dermatology and Venereology · 2002 · 9 citations
    15. Zinc-responsive Acral Hyperkeratosis as a Sequele of Acrodermatitis Enteropathica Indian Journal of Paediatric Dermatology · 2025
    16. Inherited disorders of the skin in human and mouse: from development to differentiation. The International Journal of Developmental Biology · 2004 · 25 citations
    17. Case Report of Wound Treatment with Hyiodine Gel in an Occasional KID Syndrome Patient Journal of Clinical Medicine · 2025
    18. BRAF Inhibitor Dabrafenib in Patients with Metastatic <i>BRAF</i>-Mutant Thyroid Cancer Thyroid · 2014 · 188 citations
    19. A Novel Connexin 26 Mutation in a Patient Diagnosed with Keratitis–Ichthyosis–Deafness Syndrome 2002 · 152 citations
    20. Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice Oncogene · 1997 · 147 citations
    21. Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation Molecular and cellular biology · 2002 · 108 citations
    22. Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and its Relevance for the Pachyonychia Congenita Phenotype Journal of Investigative Dermatology · 2000 · 88 citations
    23. Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease Journal of Cell Science · 2008 · 85 citations
    24. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice EMBO molecular medicine · 2014 · 81 citations
    25. Inherited ichthyoses/generalized Mendelian disorders of cornification European journal of human genetics · 2012 · 81 citations
    26. Clinical Findings, Cutaneous Pathology, and Response to Therapy in 21 Patients With Keratosis Pilaris Atrophicans Archives of dermatology · 1994 · 78 citations
    27. Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function Cell death and disease · 2018 · 74 citations
    28. Cutaneous Syndromes Produced as Side Effects of Triparanol Therapy Archives of Dermatology · 1963 · 74 citations
    29. Hidradenitis suppurativa: a review of cause and treatment 2010 · 73 citations
    30. Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis The EMBO Journal · 2013 · 65 citations