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Transgender and gender-diverse adults on hormone therapy often face drug-hormone interactions, especially with multiple psychotropic medications.

Testosterone replacement is recommended for men with low testosterone levels and symptoms of hypogonadism.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

Testosterone therapy can help improve mood, sexual function, and bone health in women with low androgen levels, but more research is needed to establish safe and effective guidelines.

Testosterone therapy can help women with androgen deficiency by improving energy, sex drive, and bone health with few side effects.

Testosterone may have a dual role in COVID-19, potentially worsening outcomes in men, and testosterone therapy could help some patients, but more research is needed.

Hormone therapy in transgender women can affect hair growth and acne, and there are specific skin issues related to gender-affirming surgery, but more research is needed on their dermatological health.

The document concludes that hormone therapy is essential for treating gender dysphoria, with specific drugs and monitoring protocols recommended for safety and effectiveness.

Testosterone therapy increases bone density in older men with low testosterone levels.

Estrogen therapy can reduce skin aging but has cancer risks.

Managing side effects of endocrine therapy is crucial to improve adherence and survival in breast cancer patients.

Menopause causes skin and hair to become drier and thinner, but hormone therapy can improve these conditions.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.

Female pattern hair loss is caused by multiple factors and while treatments like topical minoxidil, hormone therapy, and low-level light therapy can help, none can fully cure it.

Gonadal dysgenesis, like Turner's and Klinefelter's syndromes, negatively affects bone health, but hormone treatments can help.

More research is needed on the health effects of hormone therapy for transgender and nonbinary people.

The normal human prostate does not significantly affect blood DHT levels.

The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.

The document explains hair biology, the causes of hair loss, and reviews various hair loss treatments.

Facial aging is caused by natural processes and external factors, and can be managed with preventative measures and a variety of treatments tailored to individual needs.

Genetic counselors should be culturally skilled and aware of transgender patients' unique health risks and needs.

The document concludes that individualized treatment and lifestyle changes are important for managing menopause symptoms and health risks.

Many women experience sexual dysfunction, but few seek help, and better treatment and medical training are needed.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Skin problems in older people can indicate hormonal diseases, nutritional deficiencies, or conditions like diabetes, menopause, and HIV.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

The document concludes that Functional Hypothalamic Amenorrhea should be carefully diagnosed and managed to prevent health complications, using lifestyle changes and specific medications.

COVID-19 and hypopituitarism (reduced pituitary gland function) are linked, with the latter's related health issues potentially worsening COVID-19 outcomes, and COVID-19 possibly increasing risk for pituitary complications.