Search

for
Search:

GlossaryHigh-Fat Diet

diet high in fats, often over 35-40% of calories

A High-Fat Diet (HFD) is a dietary regimen where a significant portion of daily caloric intake comes from fats, often exceeding 35-40% of total calories. This type of diet is commonly used in research to study metabolic disorders, obesity, and their effects on various biological processes, including hair growth and alopecia.

Related Terms

Sort by

Research

30 / 1000+ results

Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTOR signaling: Role of Lepidium sativum seed extracts

research Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTOR signaling: Role of Lepidium sativum seed extracts

14 citations , February 2021 in “Journal of ethnopharmacology”

Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.

research Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages

6 citations , December 2022 in “Cell reports”

Eating a high-fat fish oil diet caused mice to lose hair due to a specific immune cell activity in the skin linked to a protein called E-FABP.

research The role of wood sterol in alopecia induced by high fat diet through lipid metabolism

May 2024 in “Food bioscience”

Wood sterol may help reduce hair loss caused by a high-fat diet.

research 930 High-fat diet exacerbates neutrophilic folliculitis by facilitating sequential chemokine expressions by keratinocytes and neutrophils

May 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

A high-fat diet worsens neutrophilic folliculitis by increasing certain chemokines.

research Consumption of a low-carbohydrate and high-fat diet (the ketogenic diet) exaggerates biotin deficiency in mice

10 citations , October 2013 in “Nutrition”

The ketogenic diet can worsen biotin deficiency, suggesting a need for biotin supplements.

Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19

research Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19

3 citations , September 2021 in “International Journal of Molecular Sciences”

Androgens and a high-fat diet may increase the risk of severe COVID-19 in women with PCOS by upregulating certain proteins in the heart and kidneys.

research Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity

April 2019 in “PLOS ONE”

A high-fat diet caused severe health problems in female macaques but was reversible with a normal diet, while male macaques reacted differently.

research News updates

April 2012 in “Lab Animal”

Early exposure to germs may protect against autoimmune diseases, lack of sex increases alcohol preference in fruit flies, a potential baldness treatment could involve blocking a specific receptor, skin memory cells help prevent re-infection, high-fat diets can affect brain cells related to weight, and the link between social status, stress, and heart disease in primates is unclear.

research Polycystic Ovary Syndrome (PCOS) and Other Androgen Excess–Related Conditions: Can Changes in Dietary Intake Make a Difference?

48 citations , February 2008 in “Nutrition in Clinical Practice”

Dietary changes, including weight loss and a balanced diet, are important for managing PCOS, especially in overweight women.

research The management of very low-calorie ketogenic diet in obesity outpatient clinic: a practical guide

97 citations , October 2019 in “Journal of Translational Medicine”

A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.

Association of Lifelong Intake of Barley Diet with Healthy Aging: Changes in Physical and Cognitive Functions and Intestinal Microbiome in Senescence-Accelerated Mouse-Prone 8 (SAMP8)

research Association of Lifelong Intake of Barley Diet with Healthy Aging: Changes in Physical and Cognitive Functions and Intestinal Microbiome in Senescence-Accelerated Mouse-Prone 8 (SAMP8)

18 citations , August 2019 in “Nutrients”

Eating barley for life may lead to healthier aging in mice.

research Cutaneous xanthomas with concurrent demodicosis and dermatophytosis in a cat

18 citations , July 2001 in “Australian veterinary journal”

A cat with skin bumps and itching had high blood fats and skin infections, which improved with diet and medication changes.

research The effect of dietary modulation of sulfur amino acids on cystathionine β synthase–deficient mice

14 citations , November 2015 in “Annals of the New York Academy of Sciences”

Changing the diet of mice lacking the enzyme CBS can affect symptoms related to the genetic condition.

Alleviation of hyperlipidemia, insulin resistance, and myopathy by nano selenium/ nano CoQ10 platform with simvastatin in hyperlipidemic rats; comprehensive outlook

research Alleviation of hyperlipidemia, insulin resistance, and myopathy by nano selenium/ nano CoQ10 platform with simvastatin in hyperlipidemic rats; comprehensive outlook

January 2023 in “Research Square (Research Square)”

Nano selenium and CoQ10 helped reduce blood fat levels and insulin resistance while preventing muscle damage from statin drugs in rats.

research Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells

April 2024 in “Applied biological chemistry”

Piperine from black pepper can make hair less oily by blocking fat cell development in hair roots.

$Ethyl acetate fraction of Eclipta alba: a potential phytopharmaceutical targeting adipocyte differentiation$

research Ethyl acetate fraction of Eclipta alba: a potential phytopharmaceutical targeting adipocyte differentiation

13 citations , December 2017 in “Biomedicine & Pharmacotherapy”

Eclipta alba extract may help treat obesity by blocking fat cell formation and lowering blood lipid levels.

research Metabolic dysfunction in female mice with disruption of 5α-reductase 1

11 citations , January 2017 in “Journal of Endocrinology/Journal of endocrinology”

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

research Weight loss regimens that control for carbohydrate quality or quantity: a review

5 citations , June 2008 in “Pediatric Diabetes”

Low-glycemic index diets are beneficial for weight loss and satiety, but more research is needed on long-term effects and individualized approaches are recommended.

research Tissue Resident Foxp3+ Regulatory T Cells: Sentinels and Saboteurs in Health and Disease

9 citations , March 2022 in “Frontiers in Immunology”

Foxp3+ Regulatory T Cells are important for immunity and tolerance, affect hair growth and wound healing, and their dysfunction can contribute to obesity-related diseases and other health issues.

research The Association of Polycystic Ovarian Syndrome Among Reproductive-Aged Women With Consumption of Junk Food in Jeddah, Saudi Arabia

November 2023 in “Curēus”

Eating junk food is linked to higher rates of PCOS and related symptoms in women.

research Rodent models in placental research. Implications for fetal origins of adult disease

7 citations , January 2022 in “Animal Reproduction”

Using rodents for research shows that health problems in the womb can cause diseases later in life.

research Retinoic acid exerts sexually dimorphic effects on muscle energy metabolism and function

5 citations , September 2021 in “Journal of biological chemistry/The Journal of biological chemistry”

Retinoic acid affects male and female muscle energy use and function differently.

Chemical Characterization and Ameliorating Effect of Centratherum anthelminticum Extract against Polycystic Ovary Syndrome in Wistar Rats

research Chemical Characterization and Ameliorating Effect of Centratherum anthelminticum Extract against Polycystic Ovary Syndrome in Wistar Rats

July 2023 in “International Journal of Endocrinology”

Centratherum anthelminticum seed extract effectively treats Polycystic Ovary Syndrome in rats.

research Keratin 79 is a PPARA target that is highly expressed by liver damage

1 citations , April 2023 in “Biochemical and biophysical research communications”

Keratin 79 is linked to liver damage and may help diagnose liver diseases.

Chronic Exposure of 5‐Alpha Reductase Inhibitor in Young Male Rats Induces Not Only Metabolic Disturbance, But Also Depressive‐Like Behaviors as Similar with Obese Condition

research Chronic Exposure of 5‐Alpha Reductase Inhibitor in Young Male Rats Induces Not Only Metabolic Disturbance, But Also Depressive‐Like Behaviors as Similar with Obese Condition

December 2023 in “Alzheimer's & Dementia”

Long-term use of a drug for hair loss and prostate issues can cause metabolic problems and depression-like behavior in young male rats.

research Acne: Diet and acnegenesis

11 citations , January 2011 in “Indian Dermatology Online Journal”

Eating dairy and high glycemic foods may increase the risk of acne.

research Finasteride Alleviates High Fat Associated Protein-Overload Nephropathy by Inhibiting Trimethylamine N-Oxide Synthesis and Regulating Gut Microbiota

1 citations , August 2022 in “Frontiers in Physiology”

Ameliorative Impact of High Inositol Diet on the Insulin Resistance and Metabolite Hormones among Women with Polycystic Ovary Syndrome

research Ameliorative Impact of High Inositol Diet on the Insulin Resistance and Metabolite Hormones among Women with Polycystic Ovary Syndrome

May 2022 in “Maǧallaẗ Buḥūṯ Al-Tarbiyyaẗ Al-Nawʿiyyaẗ (Print)”

Eating a high inositol diet significantly improves insulin resistance and hormone levels in women with PCOS.

research Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ

218 citations , October 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

research The Role of Individually Selected Diets in Obese Women with PCOS—A Review

4 citations , October 2022 in “Nutrients”

Personalized diets, like the Mediterranean Diet and low carb diets, can help manage PCOS symptoms in obese women, and probiotics may enhance weight loss and improve metabolic health. More research is needed to find the best diet strategies.