14 citations
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October 2020 in “Journal of ethnopharmacology” This study found that both ethanol and aqueous extracts of Lepidium sativum seeds improved insulin signaling and reduced obesity-related metabolic changes in high-fat diet-fed rats, suggesting potential as a dietary supplement.
6 citations
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December 2022 in “Cell reports” This study found that feeding mice a high-fat diet with fish oil leads to hair loss through a mechanism involving omega-3 fatty acids and TNF-α signaling, with epidermal fatty acid binding protein playing a key role.
4 citations
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January 2019 in “Evidence-based Complementary and Alternative Medicine” This study found that the Yangyin Qingre Huoxue Prescription effectively reduced the progression of atherosclerosis in mice, with lipid-regulating and anti-inflammatory functions and lower hepatotoxicity than simvastatin.
This pilot study found that a high fat lard diet may protect against fibrosis and affect the hair follicle cycle in a mouse model of systemic sclerosis, unlike a high fat coconut oil diet.
May 2024 in “Food bioscience” In this animal study, mice on a high-fat diet experienced weakened hair follicles but regained hair growth after treatment with wood sterol, which improved hair follicle health and altered hormone levels, suggesting its potential as a preventive measure for diet-induced alopecia.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that a high-fat diet in obese mice may exacerbate neutrophilic folliculitis by increasing CXCR2 ligand expression in keratinocytes and neutrophils.
This study found that switching juvenile mice from a high-fat, high-carbohydrate diet to a control diet optimally reduced hormonal imbalances and weight, with nutraceuticals offering partial support.
10 citations
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September 2013 in “Nutrition” In this animal study, the ketogenic diet was associated with more severe biotin deficiency in biotin-deficient mice, suggesting that biotin supplementation is important when following this diet.
January 2024 in “Journal of Hard Tissue Biology” In this study, researchers found that a high-fat diet in mice induced downregulation of certain Krtap genes in the tongue, which may be linked to structural issues or oral cancer risk, highlighting a potential connection between oral health and systemic diseases like metabolic syndrome.
March 2026 in “Journal of obstetrics and gynaecology research” In this study, Ark-e-Kasni was found to alleviate PCOS symptoms in rats by restoring hormonal levels, improving insulin sensitivity, and reducing inflammation and cystic follicles, suggesting its therapeutic potential via diverse molecular mechanisms.
10 citations
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November 2019 in “Journal of Traditional and Complementary Medicine” This study found that oral treatment with Chamaecyparis obtusa var. formosana leaf extracts improved glucose metabolism and reduced insulin resistance in hyperglycemic rats, suggesting potential as a diabetes health supplement.
April 2017 in “Journal of Investigative Dermatology” This study suggests that PKCß plays a critical role in modulating the dermal inflammatory microenvironment in response to dietary lipids in mice.
3 citations
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September 2021 in “International Journal of Molecular Sciences” This study suggests that women with polycystic ovary syndrome may have an increased risk of COVID-19-related cardiac and renal complications, and that weight loss through lifestyle changes could help reduce these risks.
August 2026 in “Experimental Dermatology” This study found that a high-fat diet exacerbates hair loss in female mice by increasing oxidative stress and androgen signaling in the skin, and that treatments with antioxidants or antiandrogens may help mitigate this effect.
This study found that a high-fat diet in macaques led to severe gastrointestinal inflammation and chronic wasting, with more pronounced effects in females, highlighting the potential risks of certain dietary interventions in obesity models.
48 citations
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February 2008 in “Nutrition in Clinical Practice” This article reviews dietary recommendations for managing polycystic ovary syndrome and provides evidence that diet changes can improve the androgen profile in affected women, but it reports no new clinical results.
1 citations
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August 2022 in “Frontiers in Physiology” This study suggests that finasteride may help alleviate high-fat diet-induced kidney damage in mice by reducing TMAO synthesis and regulating gut microbiota.
29 citations
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July 2013 in “Journal of Investigative Dermatology” This review explores the mechanisms by which UV radiation causes skin cancer, highlighting UV-induced DNA damage and its implications for cancer prevention strategies, but reports no new findings.
9 citations
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March 2022 in “Frontiers in Immunology” This review discusses the roles and mechanisms of tissue-resident regulatory T cells in immune regulation and tissue homeostasis, but reports no new experimental results.
May 2026 in “Frontiers in Medicine” This study found that several demographic, familial, lifestyle, and metabolic factors were independently associated with androgenic alopecia, differing by severity across various subtype classifications.
November 2023 in “Curēus” This study, conducted in Jeddah, Saudi Arabia, found that women with PCOS who consumed diets high in carbohydrates, fats, and refined sugars had a significant prevalence of obesity and struggled with weight loss, with fast food consumption notably associated with facial acne.
January 2023 in “Research Square (Research Square)” In this study, CoQ10 and selenium nanoparticles showed potential to alleviate hyperlipidemia and simvastatin-induced side effects in rats, but a triple combination with simvastatin caused intense liver and muscle damage.
45 citations
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August 2018 in “Journal of Lipid Research” This study observed that partial autotaxin deficiency in mice protects against diet-induced obesity and systemic insulin resistance, suggesting the ATX-LPA pathway negatively affects skeletal muscle insulin signaling and mitochondrial function during obesity.
November 2025 in “Journal of Scientific Research and Reports” This study found that among female college students in the Thane District, poor dietary patterns high in simple carbohydrates and saturated fats significantly increased the risk of developing PCOS, highlighting the need for nutritional education and public health interventions.
June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, mice fed various high-fat diets showed changes in dermal white adipose tissue lipid composition, with decreases in essential omega-3 fatty acids, which are important for skin health.
4 citations
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September 1977 in “Lipids” This study observed that gerbils on a fat-deficient diet had altered fatty acid composition in various organs and exhibited hair loss, reduced testis development, and often lower body weight compared to those on a fat-supplemented diet.
May 2025 in “Journal of Experimental Pharmacology” This study found that Allium ascalonicum L. extract may improve insulin resistance by increasing insulin tolerance test values and lowering blood glucose levels, though more research is needed to understand its effects on metabolic disorders.
7 citations
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January 1991 in “Comparative biochemistry and physiology. A. Comparative physiology” This study found that a dietary change in common marmosets significantly reduced in vitro erythrocyte haemolysis, improved skin lesions, and promoted complete fur regrowth, possibly due to increased vitamin E levels.
30 citations
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July 2018 in “Scientific Reports” In this study, a high-fat, high-cholesterol diet in atherosclerotic mice led to skin inflammation and hair problems, which could be reversed by inhibiting glycosphingolipid synthesis.
5 citations
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May 2025 in “Nature Communications” This study found that in mice, high-fat diets quickly reduce the skin's ability to transfer heat, while diets preventing obesity increase skin energy loss, suggesting the skin plays an active role in energy metabolism and lipid regulation.