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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Targeted cancer therapies often cause serious skin problems that need careful management.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Bioprinting could improve wound healing but needs more development to match real skin.

Peptide hydrogels heal burn wounds faster and better than standard dressings.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Early detection and intensive treatment of diseases caused by Staphylococcus aureus toxins are crucial for reducing severe health effects.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Women with epilepsy should be monitored for reproductive issues, which can be caused by epilepsy or its treatments, especially when using valproate.

Survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis need ongoing care for various long-term health problems.

COVID-19 can cause skin issues like rashes and "COVID toes," and people with skin conditions should adjust their treatments if they get the virus.

Gynecologists should provide comprehensive care for transgender patients, including mental health evaluation, hormone therapy, and surgical options, while monitoring for side effects and ensuring patient safety.

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Some people experience severe, long-lasting side effects from fluoroquinolone antibiotics, leading to the recommendation of limited use and increased awareness of these risks.

The document suggests medicine should integrate biological and cultural factors and focus on holistic, equitable care.

Pregnancy can change skin disease severity, with some conditions improving and others worsening, and treatment should balance benefits and fetal safety.

Epilepsy and certain epilepsy drugs can lead to reproductive problems in women, but changing medication might improve these issues.

In Brazil in 2018, the most common skin issues were acne, photoaging, and nonmelanoma skin cancer, with treatments often including topical medications and sunscreen.

Severe insulin resistance can be managed with medication, lifestyle changes, and treatment for related conditions.

Teriflunomide is effective and generally safe for treating relapsing-remitting multiple sclerosis.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Taking finasteride for benign prostate hyperplasia may increase the risk of osteoporosis, especially at higher doses.

Managing PCOS is hard because it varies a lot, treatments are limited, and there's a lot of false information online.

The 2018 update to the ED care model added a new severity score and stressed a detailed evaluation of both physical and psychological aspects.

Delayed ejaculation is a complex issue caused by psychological, biological, and lifestyle factors, requiring a holistic treatment approach.

Obesity increases the risk of skin infections, inflammatory conditions, and melanoma, but not basal cell carcinoma.