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    Did you mean Hair Growth Factors?
    Glossary Hair Growth Factors

    naturally occurring proteins that stimulate hair follicle growth

    Hair Growth Factors are naturally occurring proteins or compounds that stimulate hair follicles to enter the growth phase, promoting hair development and reducing hair loss. These factors, such as keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF), play crucial roles in cellular signaling pathways that regulate the hair growth cycle, making them essential in both clinical treatments for alopecia and cosmetic hair care products.

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    1. SIRT 7 activates quiescent hair follicle stem cells to ensure hair growth in mice EMBO journal · 2020 · 38 citations
    2. Hepatocyte growth factor (HGF) activator expressed in hair follicles is involved in in vitro HGF-dependent hair follicle elongation Journal of Dermatological Science · 2001 · 77 citations
    3. Hair growth enhancement via mitochondrial activation by Mito‐activator complex International Journal of Cosmetic Science · 2026
    4. Serotonin activates dermal papilla cells and promotes hair growth Scientific Reports · 2025
    5. Millet seed oil activates β–catenin signaling and promotes hair growth Frontiers in Pharmacology · 2023 · 1 citations
    6. trans-3,4'-Dimethyl-3-hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor .BETA.2 (TGF-.BETA.2) through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes Biological and Pharmaceutical Bulletin · 2008 · 10 citations
    7. CPK1 activates CNGCs through phosphorylation for Ca2+ signaling to promote root hair growth in Arabidopsis Nature Communications · 2025
    8. Cutaneous application of α-methylspermidine activates the growth of resting hair follicles in mice Amino Acids · 2009 · 12 citations
    9. KY19382, a novel activator of Wnt/β-catenin signaling, promotes hair re-growth and hair follicle neogenesis 2020
    10. 1017 The prostaglandin F2α analog bimatoprost activates secondary hair germ cells to promote hair growth through two distinct signaling pathways Journal of Investigative Dermatology · 2026
    11. Hair Cycle-Dependent Expression of Hepatocyte Growth Factor (HGF) Activator, Other Proteinases, and Proteinase Inhibitors Correlates with the Expression of HGF in Rat Hair Follicles Journal of Investigative Dermatology Symposium Proceedings · 1999 · 33 citations
    12. Phosphatidic Acid Has a Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells 2003 · 46 citations
    13. Metformin, an Activator of AMPK, Promotes the Growth of Hair Follicles via the AMPK/β-catenin Signaling Pathway Journal of Clinical Dermatology · 2019
    14. AIMP1-derived peptide secreted from hair follicle stem cells activates dermal papilla cells to promote hair growth bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 1 citations
    15. High-throughput screening of small molecule Wnt/β-catenin activators for hair and nail growth Communications Biology · 2026
    16. New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence Journal of Investigative Dermatology · 2012 · 68 citations
    17. Localization of Plasminogen Activator Inhibitor Type 2 (PAI-2) in Hair and Nail: Implications for Terminal Differentiation 1998 · 42 citations
    18. Hair growth–promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the Wnt/β-Catenin and JAK-STAT signaling pathways Archives of dermatological research · 2024
    19. LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells Frontiers in Genetics · 2020 · 12 citations
    20. Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice Scientific Reports · 2017 · 113 citations
    21. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020 · 23 citations
    22. Conditioned media obtained from human outer root sheath follicular keratinocyte culture activates signalling pathways that contribute to maintenance of hair-inducing capacity and increases trichogenicity of cultured dermal cells Experimental Dermatology · 2012 · 6 citations
    23. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012 · 85 citations
    24. KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis British Journal of Pharmacology · 2021 · 13 citations
    25. Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth British Journal of Pharmacology · 2023 · 11 citations
    26. ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth 2022
    27. Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth Scientific Reports · 2014 · 61 citations
    28. Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems Stem Cell Research & Therapy · 2019 · 17 citations
    29. Advances in hair growth Faculty reviews · 2022 · 1 citations
    30. ICP5249 Promotes Hair Growth by Activating the AMPK-Autophagy Signaling Pathway Journal of Microbiology and Biotechnology · 2024 · 5 citations