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    Glossary Glucocorticoid Resistance

    condition where tissues are less responsive to steroid hormones

    Glucocorticoid Resistance, also known as Steroid Resistance, is a condition where the body's tissues are less sensitive or unresponsive to glucocorticoids, which are a type of steroid hormone used to reduce inflammation and regulate immune responses. This can make it difficult to treat conditions like asthma, rheumatoid arthritis, and certain autoimmune diseases, as the usual doses of glucocorticoids become less effective.

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    Research 30 of 1000+

    1. Glucocorticoid Resistance Syndrome in 2 Patients With Diverse Genotype JCEM Case Reports · 2025
    2. The Glucocorticoid Resistance Syndrome. Two Cases of a Novel Pathogenic Variant in the Glucocorticoid Receptor Gene JCEM case reports · 2023
    3. LBODP010 A Case of Glucocorticoid Resistance Syndrome Journal of the Endocrine Society · 2022
    4. Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor Springer eBooks · 2016
    5. Novel insights into the molecular mechanisms underlying generalized glucocorticoid resistance and hypersensitivity syndromes Hormones · 2017 · 15 citations
    6. 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis Hormone Molecular Biology and Clinical Investigation · 2014 · 15 citations
    7. Disrupted Pancreatic Exocrine Differentiation and Malabsorption in Response to Chronic Elevated Systemic Glucocorticoid ˜The œAmerican journal of pathology · 2010 · 19 citations
    8. The Polycystic Ovary Syndrome and Acne Springer eBooks · 2014 · 2 citations
    9. Chrousos syndrome: from molecular pathogenesis to therapeutic management European Journal of Clinical Investigation · 2015 · 47 citations
    10. Acne-Associated Syndromes Springer eBooks · 2019
    11. 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents Diabetes · 2014 · 93 citations
    12. Rare Challenges in Diagnosing Cushing’s Syndrome and Primary Aldosteronism: A Case Report of a Female With a Negative Workup Curēus · 2023
    13. [Hirsutism and hypertrichosis in adults: investigations and treatment]. PubMed · 2002 · 3 citations
    14. Mucocutaneous Manifestations of Endocrine Disorders John Wiley & Sons, Ltd eBooks · 2013
    15. Treatment options for polycystic ovary syndrome International journal of women's health · 2011 · 514 citations
    16. Skin and metabolic syndrome: A review of the possible associations Journal of Research in Medical Sciences · 2021 · 3 citations
    17. Hormone therapy in acne Indian Journal of Dermatology, Venereology and Leprology · 2013 · 24 citations
    18. Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene 2002 · 94 citations
    19. A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005 · 91 citations
    20. The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopecia European Journal of Dermatology · 2011 · 42 citations
    21. A variant of the glucocorticoid receptor gene is not associated with adrenal androgen excess in women with polycystic ovary syndrome Fertility and Sterility · 2000 · 20 citations
    22. Generalised Glucocorticoid Resistance touchREVIEWS in Endocrinology · 2008 · 1 citations
    23. Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth International journal of reproductive medicine · 2014 · 222 citations
    24. Serum lipocalin-2 as an insulin resistance marker in patients with polycystic ovary syndrome Journal of Endocrinological Investigation · 2010 · 29 citations
    25. Expression of 11β-hydroxysteroid dehydrogenase type 1 in visceral and subcutaneous adipose tissues of patients with polycystic ovary syndrome is associated with adiposity The Journal of Steroid Biochemistry and Molecular Biology · 2010 · 18 citations
    26. Treatment of hyperandrogenism in polycystic ovary syndrome Cambridge University Press eBooks · 2010 · 1 citations
    27. 5α-Reduced glucocorticoids: a story of natural selection Journal of Endocrinology · 2011 · 46 citations
    28. Targets to treat androgen excess in polycystic ovary syndrome Expert Opinion on Therapeutic Targets · 2015 · 14 citations
    29. Endocrinopathies and Other Disorders Inducing a Polycystic Ovary Syndrome Phenotype S. Karger AG eBooks · 2012 · 7 citations
    30. Polycystic Ovary Syndrome in Adolescents Current Women's Health Reviews · 2010