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    Glossary Glucocorticoid Receptor

    regulates gene expression by binding to glucocorticoid hormones

    The Glucocorticoid Receptor (GR) is a type of protein found inside cells that binds to glucocorticoids, which are a class of steroid hormones. When these hormones bind to the receptor, it can influence the expression of specific genes, thereby regulating processes like inflammation, immune response, and metabolism. This receptor is crucial in medical treatments for conditions like asthma, autoimmune diseases, and even certain types of hair loss, such as alopecia areata.

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    1. Altered skin development and impaired proliferative and inflammatory responses in transgenic mice overexpressing the glucocorticoid receptor The FASEB Journal · 2001 · 92 citations
    2. A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005 · 91 citations
    3. Expression of estrogen, androgen, and glucocorticoid receptors in recent striae distensae International Journal of Dermatology · 2009 · 67 citations
    4. Recent advances in the molecular mechanisms determining tissue sensitivity to glucocorticoids: novel mutations, circadian rhythm and ligand-induced repression of the human glucocorticoid receptor BMC Endocrine Disorders · 2014 · 62 citations
    5. Ectoderm-Targeted Overexpression of the Glucocorticoid Receptor Induces Hypohidrotic Ectodermal Dysplasia Endocrinology · 2005 · 46 citations
    6. Effect of thioredoxin reductase 1 on glucocorticoid receptor activity in human outer root sheath cells Biochemical and Biophysical Research Communications · 2007 · 34 citations
    7. Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching (FRAP) Is an Integrated Measure of Receptor Function Molecular Medicine · 2004 · 31 citations
    8. A variant of the glucocorticoid receptor gene is not associated with adrenal androgen excess in women with polycystic ovary syndrome Fertility and Sterility · 2000 · 20 citations
    9. Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation The Journal of Steroid Biochemistry and Molecular Biology · 2007 · 19 citations
    10. AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells 2019 · 17 citations
    11. Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor Stem Cells Translational Medicine · 2015 · 11 citations
    12. The myeloid mineralocorticoid receptor regulates dermal angiogenesis and inflammation in glucocorticoid‐induced impaired wound healing British Journal of Pharmacology · 2022 · 9 citations
    13. Glucocorticoid and Sex Hormone Receptors: Clinical Implications and Therapeutic Relevance Dermatologic Clinics · 2007 · 4 citations
    14. Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2022 · 2 citations
    15. Why steroids may not always work in alopecia areata: elevated unoccupied glucocorticoid receptors and decreased levels of thioredoxin Dermatologic Therapy · 2001 · 2 citations
    16. Cedrol mitigates hepatic lipid accumulation and adipocyte hypertrophy induced by corticosteroids through the inhibition of glucocorticoid receptor activity Scientific Reports · 2025
    17. The Glucocorticoid Resistance Syndrome. Two Cases of a Novel Pathogenic Variant in the Glucocorticoid Receptor Gene JCEM case reports · 2023
    18. Glucocorticoid Receptor Antagonism Improves Glucose Metabolism in a Mouse Model of Polycystic Ovary Syndrome Journal of the Endocrine Society · 2023
    19. Supplementary Material for: Dexamethasone, a synthetic glucocorticoid, induces the activity of androgen receptor in human dermal papilla cells Figshare · 2022
    20. Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor Springer eBooks · 2016
    21. Polymeric micelle mediated follicular delivery of spironolactone: Targeting the mineralocorticoid receptor to prevent glucocorticoid-induced activation and delayed cutaneous wound healing International Journal of Pharmaceutics · 2021 · 9 citations
    22. The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors Drug Metabolism Reviews · 2006 · 219 citations
    23. The role of nuclear hormone receptors in cutaneous wound repair Cell Biochemistry and Function · 2014 · 68 citations
    24. The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta? Journal of Investigative Dermatology · 2006 · 65 citations
    25. Modulation of glucocorticoid action and the treatment of type-2 diabetes Best Practice & Research Clinical Endocrinology & Metabolism · 2007 · 54 citations
    26. Primary Generalized Glucocorticoid Resistance and Hypersensitivity Hormone Research in Paediatrics · 2011 · 48 citations
    27. Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An <i>in Silico</i> and <i>in Vitro</i> Study Environmental health perspectives · 2020 · 29 citations
    28. Non-canonical dimerization of the androgen receptor and other nuclear receptors: implications for human disease Endocrine Related Cancer · 2019 · 25 citations
    29. Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy 2007 · 23 citations
    30. Recent advances in the molecular mechanisms causing primary generalized glucocorticoid resistance Hormones · 2016 · 15 citations