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The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.

A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.

Topical estrogen treatments did not change hair growth in certain mouse strains, questioning previous findings on their role in hair growth control.

Blocking CRF1 receptors improved male hormone levels and reduced testicular tumor size in men with a specific adrenal condition.

Androgenetic alopecia linked to COVID-19 severity; drugs reducing androgen receptor activation may help.

Mutations in the androgen receptor gene cause Androgen Insensitivity Syndrome, affecting sexual development.

Custom software found that common allergy drugs might have new uses for various conditions and could improve survival in some cancers.

Mutations in the androgen receptor gene cause different levels of androgen insensitivity, making it hard to create simple tests for the condition.

The document concludes that Nonclassic Congenital Adrenal Hyperplasia requires personalized treatment plans to manage symptoms and fertility, with glucocorticoids being a common therapy.

CB-03-01 is a promising skin cream for treating hormone-related skin problems without causing harmful body-wide effects.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Oral antiandrogens effectively treat female hair loss, with better results in higher hair loss grades.

Nanocapsules can improve clobetasol delivery to hair follicles, reducing side effects.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.

Stress in mice delays hair growth and treatments blocking substance P can partly reverse this effect.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.

Hormones and genetics play key roles in male and female baldness, which can affect mental health and may be linked to other health issues.

Rare adrenal cancers that secrete androgens or estrogens have a poor prognosis and are treated primarily with surgery.

Antiandrogen therapy helps treat genetic hair loss.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

Estrogen receptors may not affect mouse hair growth as previously thought, and oxybenzone in sunscreen is stable in sunlight.

Women with non-classic congenital adrenal hyperplasia have higher risk for heart and metabolic problems.

Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.

The conclusion is that there is a high demand for new contraceptives that provide both pregnancy prevention and protection against STIs, along with additional health benefits.

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.