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Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Eating high-glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

The human sebocyte culture model has improved understanding of oily skin and acne, and how they can be treated.

The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.

Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

Cathepsin L is essential for normal hair growth and development.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Different types of stem cells and their environments are key to skin repair and maintenance.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Pregnancy can cause skin pigmentation, stretch marks, and changes in hair, nails, and sweat glands, with most resolving after birth.

The document concludes that accurate diagnosis of different types of hair loss requires careful examination of hair and scalp tissue, considering both clinical and microscopic features.

Different types of skin pores should be identified correctly and evaluated with suitable methods for reliable results.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

Mutant mice help researchers understand hair growth and related genetic factors.

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

Activating Nrf2 in skin cells causes skin disease similar to chloracne in mice.

The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.

Sex hormones, especially androgens, play a key role in causing acne.

Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.

Acne is a chronic disease linked to various systemic conditions and has significant psychological and social effects.

Edar signaling is crucial for proper hair follicle development and function.

Cyproterone acetate reduces hair growth and oil production.

Pregnancy often causes skin changes like darkening, stretch marks, and hair growth, which may improve after childbirth.