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    Glossary Gasdermin A3

    protein crucial for hair follicle development and growth

    Gasdermin A3 is a protein that plays a crucial role in the regulation of hair follicle development and hair growth. It is part of the gasdermin family, which is involved in cell differentiation and apoptosis (programmed cell death). Mutations or dysregulation of Gasdermin A3 can lead to hair disorders, such as alopecia, where hair loss occurs due to the disruption of normal hair follicle function.

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    Research 30 of 87

    1. Roles of GasderminA3 in Catagen–Telogen Transition During Hair Cycling Journal of Investigative Dermatology · 2015 · 25 citations
    2. N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting Journal of biomedical science · 2015 · 76 citations
    3. Inducible expression of gasdermin A3 in the epidermis causes epidermal hyperplasia and skin inflammation Experimental Dermatology · 2015 · 12 citations
    4. 880 Gasdermin A3-mediated cell death causes niche collapse and precocious activation of hair follicle stem cells Journal of Investigative Dermatology · 2019 · 2 citations
    5. Depletion of <i>Gsdma1/2/3</i> alleviates PMA-induced epidermal hyperplasia by inhibiting the EGFR–Stat3/Akt pathway Journal of Molecular Cell Biology · 2023 · 6 citations
    6. Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition Stem cell research & therapy · 2023 · 4 citations
    7. GSDMA deficiency impairs cutaneous squamous cell carcinoma growth Frontiers in Oncology · 2026
    8. Lichen Planopilaris Elsevier eBooks · 2018
    9. Androgen modulation of Wnt/β-catenin signaling in androgenetic alopecia Archives of Dermatological Research · 2018 · 39 citations
    10. Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway Oncotarget · 2017 · 11 citations
    11. Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle Stem Cells International · 2017 · 8 citations
    12. An Overview of Alopecias Cold Spring Harbor Perspectives in Medicine · 2014 · 53 citations
    13. Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: An update Journal of Dermatological Science · 2012 · 52 citations
    14. The Hair Follicle Toxicologic pathology · 2016 · 28 citations
    15. Cicatricial Alopecia Research Foundation meeting, May 2016: Progress towards the diagnosis, treatment and cure of primary cicatricial alopecias Experimental Dermatology · 2018 · 22 citations
    16. Effect of Polarized Light Therapy on Hair Regrowth in Alopecia Areata 2018
    17. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005 · 417 citations
    18. Regulation of pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway (Review) Molecular Medicine Reports · 2021 · 18 citations
    19. The concealed side of caspases: beyond a killer of cells Cellular and Molecular Life Sciences · 2024 · 13 citations
    20. Upregulation of interfollicular epidermal and hair infundibulum β-catenin expression in Gsdma3 mutant mice Acta histochemica · 2012 · 11 citations
    21. Synergistic Wound Healing: Unraveling the Multi-Target Effects of Traditional Chinese Medicine and Its Biomaterials on Chronic Wound Pathways International Journal of Nanomedicine · 2025 · 5 citations
    22. Aberrant inflammasome activation as a driving force of human autoimmune skin disease Frontiers in immunology · 2023 · 3 citations
    23. Paternal Finasteride Treatment Can Influence the Testicular Transcriptome Profile of Male Offspring—Preliminary Study Current Issues in Molecular Biology · 2021 · 1 citations
    24. Immune Microenvironment of Hair Follicles in Tumor Immunotherapy ImmunoTargets and Therapy · 2026
    25. Prevalence of MMP-1 rs1799750 Polymorphism in Androgenetic Alopecia: A Cross-Sectional Study in an Indonesia Population Molecular and Cellular Biomedical Sciences · 2025
    26. Advances in the Molecular Pathogenesis and Targeted Therapy of Psoriasis Galen Medical Journal · 2025
    27. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    28. Signaling pathways and targeted therapeutic strategies for polycystic ovary syndrome Frontiers in endocrinology · 2023
    29. Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration Histochemistry and Cell Biology · 2017 · 30 citations
    30. Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation American Journal Of Pathology · 2011 · 54 citations