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    Glossary FOXA1

    gene encoding a transcription factor influencing hair follicle development

    FOXA1, or Forkhead Box A1, is a gene that encodes a transcription factor involved in regulating the expression of other genes. It plays a crucial role in the development and function of various tissues, including the liver, lungs, and prostate. In the context of hair biology, FOXA1 can influence hair follicle development and cycling, and its dysregulation may be implicated in conditions like alopecia.

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    Research 30 of 946

    1. Hydroxychloroquine modulates the progression of experimentally induced benign prostatic hyperplasia in rats via targeting EGFR/ERK/STAT3 and AR/FOXO1/TRAIL pathways: computational and in vivo studies Scientific Reports · 2025 · 1 citations
    2. Gene expression of FOXA1 and CCL2 in different phenotypes of infertile women with polycystic ovarian syndrome Egyptian Journal of Basic and Applied Sciences · 2025
    3. Foxc1 reinforces quiescence in self-renewing hair follicle stem cells Science · 2016 · 142 citations
    4. Control of hair follicle cell fate by underlying mesenchyme through a CSL–Wnt5a–FoxN1 regulatory axis Genes & development · 2010 · 95 citations
    5. FOXE1, A New Transcriptional Target of GLI2 Is Expressed in Human Epidermis and Basal Cell Carcinoma Journal of Investigative Dermatology · 2004 · 92 citations
    6. FOXO1, TGF-β Regulation and Wound Healing International Journal of Molecular Sciences · 2014 · 87 citations
    7. FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program Frontiers in Immunology · 2013 · 69 citations
    8. The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation 2010 · 68 citations
    9. Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation Developmental Biology · 2008 · 67 citations
    10. Evidence That the Satin Hair Mutant Gene Foxq1 Is among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 during Hair Follicle Differentiation 2006 · 65 citations
    11. FOXN1 Is Critical for Onycholemmal Terminal Differentiation in Nude (Foxn1nu) Mice 2004 · 58 citations
    12. Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis American journal of human genetics · 2019 · 53 citations
    13. Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling PloS one · 2012 · 35 citations
    14. FOXN1 Deficiency: from the Discovery to Novel Therapeutic Approaches Journal of clinical immunology · 2017 · 33 citations
    15. FOXN1 deficient nude severe combined immunodeficiency Orphanet journal of rare diseases · 2017 · 32 citations
    16. Human FOXN1-Deficiency Is Associated with αβ Double-Negative and FoxP3+ T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation PloS one · 2012 · 32 citations
    17. Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations Journal of Clinical Immunology · 2021 · 30 citations
    18. Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C Differentiation · 2007 · 26 citations
    19. Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress during Hair Cycling PloS one · 2015 · 22 citations
    20. Human ClinicalPhenotype Associated with FOXN1 Mutations Advances in experimental medicine and biology · 2009 · 22 citations
    21. Foxn1 in Skin Development, Homeostasis and Wound Healing International Journal of Molecular Sciences · 2018 · 21 citations
    22. Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium Journal of molecular medicine · 2010 · 21 citations
    23. FOXN1 Italian founder mutation in Indian family: Implications in prenatal diagnosis Gene · 2017 · 17 citations
    24. Biological significance of FoxN1 gain-of-function mutations during T and B lymphopoiesis in juvenile mice Cell death and disease · 2014 · 16 citations
    25. Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche PloS one · 2013 · 6 citations
    26. Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes Frontiers in Cell and Developmental Biology · 2020 · 5 citations
    27. Suppression of FOXO1 activity by SIRT1-mediated deacetylation weakening the intratumoral androgen autocrine function in glioblastoma Cancer Gene Therapy · 2025 · 2 citations
    28. Knockdown of miR-361-5p promotes the induced activation of SHF-stem cells through FOXM1 mediated Wnt/β-catenin pathway in cashmere goats Animal Biotechnology · 2024 · 1 citations
    29. Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia 2022 · 1 citations
    30. 321 Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia 2021 · 1 citations