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GlossaryForkhead box proteins

transcription factors regulating gene expression in various processes

Forkhead box proteins, often abbreviated as FOX proteins, are a family of transcription factors that play crucial roles in regulating the expression of genes involved in various biological processes, including cell growth, differentiation, and longevity. They are named for their distinct DNA-binding domain, which resembles the shape of a forkhead. These proteins are essential for normal development and function, and mutations in FOX genes can lead to a variety of diseases, including cancer and developmental disorders.

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Taking advantage from phenotype variability in a local animal genetic resource: identification of genomic regions associated with the hairless phenotype in Casertana pigs

research Taking advantage from phenotype variability in a local animal genetic resource: identification of genomic regions associated with the hairless phenotype in Casertana pigs

16 citations , April 2018 in “Animal Genetics”

Researchers found two genes that may explain why some Casertana pigs don't have hair.

research Foxp3 Post-translational Modifications and Treg Suppressive Activity

82 citations , October 2019 in “Frontiers in Immunology”

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

research Analogs of human genetic skin disease in domesticated animals

3 citations , September 2017 in “International journal of women’s dermatology”

Some domesticated animals have the same genetic skin diseases as humans, which can help doctors understand human genetic mutations.

research Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth

222 citations , January 2014 in “International journal of reproductive medicine”

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

research Keratin K15 as a Biomarker of Epidermal Stem Cells

85 citations , September 2013 in “International Journal of Molecular Sciences”

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

research Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling

35 citations , June 2012 in “PloS one”

Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.

research Extraskeletal actions of vitamin D

119 citations , July 2016 in “Annals of the New York Academy of Sciences”

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

research Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

93 citations , April 2016 in “British Journal of Dermatology”

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

research Patients with Compound Heterozygous Mutations in Forkhead Box N1 have a Severe Immunodeficiency while Maintaining Normal Skin and Hair Development

May 2017 in “The journal of immunology/The Journal of immunology”

Patients with certain FoxN1 gene mutations have severe immune issues but normal skin and hair.

research FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program

69 citations , January 2013 in “Frontiers in Immunology”

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

research Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients

24 citations , March 2017 in “Archives of Gynecology and Obstetrics”

The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.

research A comparison of transcriptomic patterns measured in the skin of Chinese fine and coarse wool sheep breeds

17 citations , October 2017 in “Scientific reports”

Fine wool sheep have more genes for wool quality, while coarse wool sheep have more for skin and muscle traits.

research Transforming growth factor-β in stem cells and tissue homeostasis

245 citations , January 2018 in “Bone Research”

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

research Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity

66 citations , January 2017 in “Acta dermato-venereologica”

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

research Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter (PM10) on Human Dermal Fibroblasts

68 citations , September 2018 in “International Journal of Molecular Sciences”

Air pollution (PM10) increases skin inflammation and aging by reducing collagen and may trigger a repair response in skin cells.

research Dietary Influences on Skin Health in Common Dermatological Disorders

February 2024 in “Curēus”

A balanced diet with proteins, vitamins, and minerals is crucial for managing skin disorders.

research Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences

April 2024 in “International journal of molecular sciences”

Alopecia areata and vitiligo share immune system dysfunction but differ in specific immune responses and affected areas.

Faculty Opinions recommendation of Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

research Faculty Opinions recommendation of Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

October 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Six new genes linked to early hair loss were found, which also surprisingly connect to Parkinson's disease and lower fertility.

research Faculty Opinions recommendation of Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

October 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Six new genes linked to early hair loss were found, which also surprisingly connect to Parkinson's disease and lower fertility.

research Effects of Baicalin on Alopecia and the Associated Mechanism

2 citations , November 2022 in “BioMed Research International”

Baicalin may help treat hair loss by promoting hair follicle growth and activating specific cellular pathways.

Logic-based modeling and drug repurposing for the prediction of novel therapeutic targets and combination regimens against E2F1-driven melanoma progression

research Logic-based modeling and drug repurposing for the prediction of novel therapeutic targets and combination regimens against E2F1-driven melanoma progression

1 citations , November 2023 in “BMC chemistry”

Tadalafil and Finasteride may help treat aggressive melanoma.

research Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology

June 2019 in “International journal of dermatology and venereology”

The Hedgehog Signaling Pathway is important for skin and hair development and skin cancer treatment, but more research is needed to understand it fully.

research Transcription factor FOXC1 positively regulates SFRP1 expression in androgenetic alopecia

May 2021 in “Experimental Cell Research”

FOXC1 boosts SFRP1 in hair loss, suggesting new treatments.

research Regulatory T Cells: the Many Faces of Foxp3

125 citations , September 2019 in “Journal of Clinical Immunology”

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

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Related Terms

Research

research Taking advantage from phenotype variability in a local animal genetic resource: identification of genomic regions associated with the hairless phenotype in Casertana pigs

research Foxp3 Post-translational Modifications and Treg Suppressive Activity

research Analogs of human genetic skin disease in domesticated animals

research Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth

research Keratin K15 as a Biomarker of Epidermal Stem Cells

research Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling

research Extraskeletal actions of vitamin D

research Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet

research Patients with Compound Heterozygous Mutations in Forkhead Box N1 have a Severe Immunodeficiency while Maintaining Normal Skin and Hair Development

research FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program

research Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients

research A comparison of transcriptomic patterns measured in the skin of Chinese fine and coarse wool sheep breeds

research Transforming growth factor-β in stem cells and tissue homeostasis

research Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity

research Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter (PM10) on Human Dermal Fibroblasts

research Dietary Influences on Skin Health in Common Dermatological Disorders

research Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences

research Faculty Opinions recommendation of Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

research Faculty Opinions recommendation of Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

research Effects of Baicalin on Alopecia and the Associated Mechanism

research Logic-based modeling and drug repurposing for the prediction of novel therapeutic targets and combination regimens against E2F1-driven melanoma progression

research Roles of the Hedgehog Signaling Pathway in Cutaneous Physiology and Oncology

research Transcription factor FOXC1 positively regulates SFRP1 expression in androgenetic alopecia

research Regulatory T Cells: the Many Faces of Foxp3

research Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes

research From neural crest cells to melanocytes: cellular plasticity during development and beyond

research Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

research Wnt/β‐catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration

research FOXN1 Deficiency: from the Discovery to Novel Therapeutic Approaches

research FOXN1 deficient nude severe combined immunodeficiency