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    Glossary Forkhead box proteins

    transcription factors regulating gene expression in various processes

    Forkhead box proteins, often abbreviated as FOX proteins, are a family of transcription factors that play crucial roles in regulating the expression of genes involved in various biological processes, including cell growth, differentiation, and longevity. They are named for their distinct DNA-binding domain, which resembles the shape of a forkhead. These proteins are essential for normal development and function, and mutations in FOX genes can lead to a variety of diseases, including cancer and developmental disorders.

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    1. Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and their relationship with diet British Journal of Dermatology · 2016 · 93 citations
    2. Compound Heterozygous Mutations in <i>Forkhead Box N1</i> (<i>FOXN1</i>) Lead to a Severe Immunodeficiency but Normal Hair and Nail Development in Patients 2018
    3. Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration Digital Commons - RU (Rockefeller University) · 2025
    4. Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders Frontiers in Immunology · 2020 · 20 citations
    5. Patients with Compound Heterozygous Mutations in Forkhead Box N1 have a Severe Immunodeficiency while Maintaining Normal Skin and Hair Development 2017
    6. Elastogenesis Stimulation by Minoxidil or Nebivolol Reduces Premature Aging of the Aortic Wall in Diabetic Mice 2024
    7. 321 Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia 2021 · 1 citations
    8. FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program Frontiers in Immunology · 2013 · 69 citations
    9. The role of protein lactylation in skin diseases: from molecular mechanisms to potential therapeutics Frontiers in Immunology · 2026
    10. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update Clinical, Cosmetic and Investigational Dermatology · 2015 · 138 citations
    11. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    12. HuR ablation destabilizes Foxp3 mRNA and impairs regulatory T cell function, contributing to an autoimmune phenotype Frontiers in Immunology · 2025 · 1 citations
    13. Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia PLoS ONE · 2007 · 77 citations
    14. Morpho-Regulation of Ectodermal Organs ˜The œAmerican journal of pathology · 2004 · 131 citations
    15. Transforming growth factor-β in stem cells and tissue homeostasis Bone Research · 2018 · 245 citations
    16. Vpliv prehrane na pojavnost aken Repository of the University of Primorsk (University of Primorska) · 2023
    17. A preliminary study of differentially expressed genes in expanded skin and normal skin: implications for adult skin regeneration Archives of Dermatological Research · 2011 · 16 citations
    18. The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in the Hair Follicle Morphogenesis and Homeostasis American Journal of Pathology · 2006 · 9 citations
    19. Precision therapeutics in non-scarring alopecia: a systemic genomic and pathway-based framework for targeted interventions ADMET & DMPK · 2025
    20. Multi-ancestry tandem repeat association study of hair colour using exome-wide sequencing bioRxiv (Cold Spring Harbor Laboratory) · 2024
    21. Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression PloS one · 2016 · 14 citations
    22. Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients Archives of Gynecology and Obstetrics · 2017 · 24 citations
    23. Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche PloS one · 2013 · 6 citations
    24. Effects of Baicalin on Alopecia and the Associated Mechanism BioMed Research International · 2022 · 2 citations
    25. A comparison of transcriptomic patterns measured in the skin of Chinese fine and coarse wool sheep breeds Scientific reports · 2017 · 17 citations
    26. Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome Journal of Clinical Investigation · 2022 · 9 citations
    27. Molecular Mechanisms Regulating Hair Follicle Development 2002 · 854 citations
    28. CXXC5: A novel regulator and coordinator of TGF-β, BMP and Wnt signaling Journal of Cellular and Molecular Medicine · 2018 · 28 citations
    29. Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses Nature Genetics · 2015 · 73 citations
    30. Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues The Journal of Physiology · 2015 · 8 citations