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    Did you mean Myofibroblast Differentiation?
    Glossary Myofibroblast Differentiation

    process where fibroblasts transform into wound-healing myofibroblasts

    Myofibroblast differentiation is the process by which fibroblasts, a type of cell found in connective tissue, transform into myofibroblasts. These myofibroblasts play a crucial role in wound healing and tissue repair by contracting and producing extracellular matrix components, which help close wounds and restore tissue integrity. However, excessive myofibroblast activity can lead to fibrosis, a condition characterized by excessive tissue scarring.

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    Research 30 of 1000+

    1. Dendritic Cell–Associated MARCKSL1 Regulates Fibroblast Differentiation During Wound Healing Wound Repair and Regeneration · 2026
    2. Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts Journal of dermatological science · 2019 · 20 citations
    3. 854 Dermal fibroblasts enhance growth factors production by androgens, and modulate keratinocyte proliferation and differentiation 2018
    4. Differentiation of human hair follicle stem cells into endothelial cells induced by vascular endothelial and basic fibroblast growth factors Molecular Medicine Reports · 2013 · 24 citations
    5. Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart PLOS ONE · 2015 · 44 citations
    6. Differentiation capacity of stromal fibroblast-like cells from human bone marrow, adipose tissue, hair follicle dermal papilla and derma Cell and tissue biology · 2009 · 7 citations
    7. Bone morphogenetic proteins 4 and 2/7 induce osteogenic differentiation of mouse skin derived fibroblast and dermal papilla cells Cell and Tissue Research · 2013 · 28 citations
    8. Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation Development · 2012 · 207 citations
    9. Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing Frontiers in Immunology · 2022 · 20 citations
    10. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    11. Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    12. Comprehensive RNA sequencing in primary murine keratinocytes and fibroblasts identifies novel biomarkers and provides potential therapeutic targets for skin-related diseases Cellular & Molecular Biology Letters · 2021 · 17 citations
    13. RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development Orphanet journal of rare diseases · 2022 · 5 citations
    14. Growth factor mimetics for skin regeneration: In vitro profiling of primary human fibroblasts and keratinocytes Archiv der Pharmazie · 2021 · 3 citations
    15. MicroRNA-149-Mediated MAPK1/ERK2 Suppression Attenuates Hair Follicle Stem Cell Differentiation Human Gene Therapy · 2022 · 2 citations
    16. Enhanced Differentiation Potential of Pigmented Human Epidermal Equivalents 2026
    17. Equine adipose tissue derived stem cells and their multilineage differentiation Kocatepe Veterinary Journal · 2020
    18. Recombinant Human Annexin A5 Ameliorates Localized Scleroderma by Inhibiting the Activation of Fibroblasts and Macrophages Pharmaceutics · 2025
    19. Lineage Identity and Location within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin Journal of Investigative Dermatology · 2018 · 159 citations
    20. Regulation of adipocyte dedifferentiation at the skin wound edge bioRxiv (Cold Spring Harbor Laboratory) · 2023
    21. Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    22. Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice Journal of Clinical Investigation · 2019 · 136 citations
    23. Fibroblast growth factor and epidermal growth factor in hair development 1993 · 39 citations
    24. Single‐cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts Experimental Dermatology · 2020 · 35 citations
    25. Proliferation and differentiation of organoid hair follicle cells co-cultured with fat cells in collagen gel matrix culture British Journal of Dermatology · 1998 · 30 citations
    26. Combination of media, biomaterials and extracellular matrix proteins to enhance the differentiation of neural stem/precursor cells into neurons Acta Biomaterialia · 2012 · 25 citations
    27. A Potential Differentiation of Adipose and Hair Follicle-derived Mesenchymal Stem Cells to Generate Neurons Induced with EGF, FGF, PDGF and Forskolin Research Journal of Pharmacy and Technology · 2020 · 14 citations
    28. LncRNA RP11-818O24.3 regulates proliferation and differentiation of hair follicle stem cells by targeting FGF2/PI3K/AKT pathway PLoS ONE · 2025 · 1 citations
    29. Growth Differentiation Factor 11 (GDF11)/Transforming Growth Factor - β (TGF - β)/Mesenchymal Stem Cells (MSCs) Balance: A Complicated Partnership in Skin Rejuvenation Journal of Embryology & Stem Cell Research · 2019 · 1 citations
    30. 588 Skin fibroblast heterogeneity and plasticity are determined by the local niche Journal of Investigative Dermatology · 2019