21 citations
,
November 2014 in “Journal of Endocrinological Investigation” This review discusses cross-sex hormone therapy for managing gender dysphoria in transsexual individuals and reports no new clinical results; it highlights the need for education and culturally sensitive training for healthcare professionals.
This article reviews the role of hormones in human penis development and associated conditions due to hormonal imbalances, but reports no new findings, suggesting hormone replacement can manage some conditions.
989 citations
,
August 2007 in “The Lancet” This article reviews the clinical features, diagnostic criteria, and possible genetic and environmental influences of polycystic ovary syndrome but provides no new research findings.
855 citations
,
June 2009 in “The Journal of Clinical Endocrinology & Metabolism” The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.
815 citations
,
April 2010 in “The Journal of Clinical Endocrinology & Metabolism” This review examines the relationship between polycystic ovary syndrome and cardiovascular disease risk, but reports no new clinical findings; the panel calls for guidelines to prevent CVD in this population.
298 citations
,
July 2000 in “The Journal of Clinical Endocrinology and Metabolism” This study found a 6.5% prevalence of polycystic ovary syndrome among a population of Caucasian women in Spain, based on specific endocrine criteria.
286 citations
,
January 2009 in “Human Reproduction Update” This study reports that NIH PCOS is linked to more severe metabolic issues, including higher obesity and insulin resistance, compared to non-NIH PCOS phenotypes.
251 citations
,
October 2014 in “The Journal of Clinical Endocrinology & Metabolism” The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.
209 citations
,
September 2008 in “Dermatologic Therapy” This review discusses the role of androgens in hair follicle regulation and suggests that a better understanding could enhance treatments for conditions like hirsutism and alopecia, but does not present new findings.
198 citations
,
July 2011 in “Cochrane library” This study found that lifestyle interventions improved body composition, hyperandrogenism, and insulin resistance in women with PCOS, but did not affect glucose tolerance, lipid profiles, or clinical reproductive outcomes.
146 citations
,
December 2016 in “Translational Andrology and Urology” This review discusses the creation of transgender-specific guidelines by WPATH and the Endocrine Society, based mostly on clinical experience, and reports no new results.
130 citations
,
October 2006 in “Allergy” This review discusses hypersensitivity reactions to anticoagulants, highlighting the importance of early diagnosis and exploring various diagnostic and management options, but it presents no new clinical findings.
93 citations
,
February 2009 in “Annals of the New York Academy of Sciences” This review describes the roles of 5α-reductase isozymes in prostate development and pathology and reports no new clinical results.
91 citations
,
January 2009 in “International Journal of Trichology” This review discusses the advantages and limitations of various hair loss evaluation methods but reports no new results; it emphasizes the importance of cautious interpretation for these diagnostic tools.
86 citations
,
May 2013 in “American journal of obstetrics and gynecology” This article reviews the care of transgender patients, encompassing diagnosis, treatment options, and challenges in health care access, but does not present new research findings; the authors emphasize the critical role of providers in addressing transgender health needs.
77 citations
,
May 2012 in “Expert Opinion on Emerging Drugs” New treatments for male hypogonadism are effective and should be personalized.
75 citations
,
July 2013 in “The Journal of Clinical Endocrinology and Metabolism” This study found that combining low-dose spironolactone with metformin provided greater clinical benefits and improved treatment compliance in women with PCOS compared to either drug alone.
70 citations
,
March 2016 in “Urologic Clinics of North America” This article reviews the coordination of the hypothalamic-pituitary-gonadal axis, male fertility, and therapies for hypogonadism, but reports no new clinical findings.
66 citations
,
October 2013 in “Current Opinion in Endocrinology, Diabetes and Obesity” This review offers transgender hormone treatment guidelines to assist healthcare providers in improving transgender patients' access to and outcomes of medical care, but it reports no new clinical results.
60 citations
,
February 2010 in “Gynecological Endocrinology” This study suggests that adding metformin to diet and exercise improves insulin resistance and hyperandrogenism in women with PCOS, though lifestyle changes alone may enhance menstrual cycles.
60 citations
,
January 2023 in “Biogerontology” This review examines testosterone's role in male health and aging but reports no new clinical results; the authors highlight the need for further research on optimal testosterone levels to prevent age-related conditions.
58 citations
,
January 2013 in “The Journal of Clinical Endocrinology and Metabolism” This study suggests that sexual dimorphism in adipose tissue functions may be linked to androgen levels, as women with PCOS demonstrated a more masculine adipokine expression pattern.
57 citations
,
December 2018 in “JAMA Surgery” This systematic review suggests that current evidence does not support routinely discontinuing gender-affirming hormone treatments before surgery, especially testosterone and spironolactone, due to limited data on related perioperative risks.
56 citations
,
July 2008 in “European journal of endocrinology” This study found that a 6-month treatment with either metformin or rosiglitazone significantly improved endothelial function in young women with PCOS without any one drug being superior.
55 citations
,
January 2007 in “Climacteric” This paper reviews guidelines discussed at a meeting about research and practice themes, but reports no new research findings.
54 citations
,
April 2010 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism” This review discusses 46,XY disorders of sex development caused by defects in androgen production and highlights the need for long-term care from experienced multidisciplinary teams, but it reports no new clinical findings.
54 citations
,
February 1993 in “Endocrine reviews” This review examines the physiological role of androgen conjugates in cutaneous androgen metabolism and questions their association with hirsutism, without presenting new clinical findings.
53 citations
,
July 2014 in “American Journal of Physiology-Endocrinology and Metabolism” This study found that testosterone-enanthate increased red blood cell production and altered iron homeostasis in older hypogonadal men without being affected by finasteride, indicating these effects do not require type II 5α-reductase enzyme activity.
53 citations
,
May 1986 in “Clinics in endocrinology and metabolism” This review discusses the influence of androgens on hair and sebaceous growth, emphasizing that response may depend more on peripheral sensitivity than on hormone levels; it reports no new empirical results.
52 citations
,
June 2013 in “The Journal of Clinical Endocrinology and Metabolism” This study defined menstrual phase-specific reference intervals for circulating androgen levels in young women, highlighting that anovulatory females showed higher androgen, LH, and FSH levels compared to ovulatory females.