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Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The new particle system could be a promising treatment for diseases related to the 5-α reductase enzyme.

Cytochrome P-450 enzymes in the skin help break down various substances and could be targeted to treat skin conditions.

The supplement highlighted advancements and challenges in plastic and reconstructive surgery, including the impact of smoking, chemotherapy, and new treatments like Tafluprost for hair loss.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.

Some common medications can harm male fertility, but many effects can be reversed.

New treatments for male hypogonadism are effective and should be personalized.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Nonclassic adrenal hyperplasia is a genetic condition that can cause early puberty and fertility problems, treated with specific steroids.

Wnt10b makes hair follicles bigger, but DKK1 can reverse this effect.

Taking DHEA for a year is generally safe for postmenopausal women but may cause acne and more facial hair without improving metabolism or aging.

Hormonal therapies are safe and effective for treating adult women's acne.

Insulin-lowering medications show promise for PCOS symptoms but can't be the main treatment yet due to limited long-term research.

Hirsutism is excessive male-pattern hair growth in women, often caused by hormonal imbalances, and requires ongoing treatment to manage.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Insulin resistance in women with PCOS can lead to serious health issues, but lifestyle changes and certain medications can help manage symptoms.

Microneedling helps increase the absorption of a melanin product into hair follicles, which may improve laser hair removal effectiveness.

The document concludes that more research is needed to fully understand the causes of PCOS.

Oral contraceptives may cause hair loss in women.

Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.

The modified Direct Hair Transplantation method is effective for treating baldness with better graft survival and less damage than standard techniques.

New treatments for excessive hair growth in women include insulin modulators and enzyme inhibitors.

Excessive hair growth in women can be harmless or signal serious health issues, and treatment often includes medication and hair removal, with noticeable results after 3-6 months.