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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The document concludes that non-operative treatment for gender dysphoria is safe and effective, and hormone therapy does not increase cancer risk.

Testosterone therapy can help improve sexual desire and function in postmenopausal women but may cause side effects and is not FDA-approved for this use.

The document concludes that hormone therapy is essential for treating gender dysphoria, with specific drugs and monitoring protocols recommended for safety and effectiveness.

With careful management, people with congenital adrenal hyperplasia can have successful pregnancies and become parents.

Spironolactone can cause side effects like irregular bleeding, but lower doses may reduce these effects and still improve hirsutism.

Birth control pills with low-dose estrogen and antiandrogenic progestins can effectively treat acne.

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

Flutamide, an antiandrogen, has minimal impact on female rat endocrine systems and does not significantly change their reproductive cycles.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Androgen excess disorders in women were effectively treated with spironolactone, estrogen, and dexamethasone.

Some birth control pills can cause hair loss, and switching to ones with less androgen should help.

Dihydrotestosterone makes arteries stiffer in female mice by reducing estrogen receptor expression.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

Hormonal antiandrogen therapy for acne is underused and can reduce the need for antibiotics.

Hormone therapy increases the risk of heart-related issues in transgender women and may affect heart health in transgender men.

Gender-affirming therapy can cause skin issues like acne and hair loss in transgender adolescents, and more research is needed on its dermatological effects.

Certain drugs can worsen hair loss in people prone to androgenetic alopecia.

Women with lichen planopilaris often have thyroid disease, depression, anxiety, and may respond to treatment with slowed disease progression.

Only minoxidil and finasteride are FDA-approved for hair loss, with other treatments available but less effective or with side effects.

Menopause causes significant changes in the vaginal introitus, but less so in the labia majora, which may lead to symptoms of vaginal atrophy.

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

Hormonal therapy is a treatment option for acne, the only medical treatment for hirsutism, and the most promising for androgenetic alopecia.

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.

Premature ovarian insufficiency (POI) can harm women's sexual health, and they may benefit from hormone therapy and counseling.

Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.

New treatments for low male hormones improved sexual function and mood but had unclear risks, especially for older men.

Testosterone therapy is beneficial for women's health and does not cause masculinization or liver damage, and it protects the heart and breasts.

Testosterone therapy can help women with androgen deficiency by improving energy, sex drive, and bone health with few side effects.

Estrogens and progesterone are key in regulating melasma pigmentation.