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Self-amplifying RNA could be a better option for protein replacement therapy with lower doses and lasting effects, but delivering it into cells is still challenging.

Autologous Platelet and Extracellular Vesicle-Rich Plasma (PVRP) has potential in enhancing tissue regeneration and improving hair conditions, but its effectiveness varies due to individual differences.

Sweat hypersensitivity can cause severe skin issues in horses.

The horse had a rare disease causing weight loss and skin issues, leading to euthanasia due to poor treatment options.

Trichophyton bullosum has been found causing severe skin infections in donkeys in North Africa for the first time since 1933.

Testosterone therapy may slightly improve sexual function in postmenopausal women, but its long-term safety is unknown.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Future osteoporosis treatments should focus on increasing bone growth, with many promising options available.

Acankoreoside J from Acanthopanax koreanum may help promote hair growth.

Norgalanthamine from Crinum asiaticum may help hair grow.

An alpaca acted like a male and couldn't have babies because of a benign tumor in its ovary that caused high testosterone levels.

Finasteride treatment changes Cx43 in rat testes, possibly causing fertility issues.

Dogs with dermatitis show significant skin changes and higher white blood cell counts.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Low-oxygen conditions and ECM degradation products increase the healing abilities of perivascular stem cells.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Androgens play a role in female sexual function, and testosterone therapy can help women with low sexual desire, but more research is needed on treatments and long-term safety.

Estrogens and SERMs can help with skin aging, but their safety and effectiveness need more research.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

Eclipta alba has many health benefits and contains compounds with potential for drug development.

DHEA did not improve sexual function, well-being, or menopausal symptoms in postmenopausal women with low libido but caused side effects like acne and increased facial hair.

High testosterone to epitestosterone ratio in hair could predict male-pattern baldness.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Testosterone may help increase sexual events for women with low libido due to antidepressants.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.