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    Glossary Epithelial Stem Cells

    cells that regenerate and repair skin and hair follicles

    Epithelial Stem Cells are a type of stem cell found in the epithelial tissues, which line the surfaces and cavities of organs and structures throughout the body, including the skin and hair follicles. These cells have the unique ability to self-renew and differentiate into various specialized cell types, playing a crucial role in tissue repair, regeneration, and maintaining the integrity of the epithelial layers.

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    1. Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche The Journal of Pathology · 2013 · 220 citations
    2. Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices Cell · 2017 · 214 citations
    3. 09-P006 Epithelial–mesenchymal interactions promote hair follicle neogenesis and a new stem cell niche in adult corneal epithelium Mechanisms of Development · 2009
    4. The Epithelial Stem Cell Niche in Skin Elsevier eBooks · 2017 · 9 citations
    5. Tooth, hair and claw: Comparing epithelial stem cell niches of ectodermal appendages Experimental Cell Research · 2014 · 14 citations
    6. Human epithelial stem cell survival within their niche requires “tonic” cannabinoid receptor 1‐signalling—Lessons from the hair follicle Experimental Dermatology · 2021 · 14 citations
    7. Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche PloS one · 2013 · 6 citations
    8. The Dynamic Duo: Niche/Stem Cell Interdependency Stem Cell Reports · 2015 · 31 citations
    9. 687 BMP signaling in the hair follicle stem cell niche regulates hair growth and skin pigmentation 2016
    10. Stem cell dynamics in the hair follicle niche Seminars in Cell & Developmental Biology · 2013 · 135 citations
    11. Vascular endothelial cells as signaling niches for epithelial stem cells in the skin Frontiers in Cell and Developmental Biology · 2026
    12. 440 Charting the Spatially Resolved Hair Follicle Stem Cell Niche: A Multi-Omics Atlas of Healthy and Diseased Scalp Journal of Investigative Dermatology · 2025
    13. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015 · 129 citations
    14. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014 · 149 citations
    15. Dormancy in the stem cell niche Stem Cell Research & Therapy · 2012 · 29 citations
    16. 320 Desmoglein 3-mediated mechanical transadhesion controls epithelial stem cell quiescence 2021
    17. Signaling in the stem cell niche: regulating cell fate, function and plasticity Development · 2018 · 139 citations
    18. Krox20 in epithelial and glial stem cells and their niches Advances in stem cells and their niches · 2019
    19. Fully functional hair follicle organ regeneration using organ-inductive potential stem cells with an accessory mesenchymal cell population in an in vitro culture system Biochemical and Biophysical Research Communications · 2026
    20. From Hair to Cornea: Toward the Therapeutic Use of Hair Follicle-Derived Stem Cells in the Treatment of Limbal Stem Cell Deficiency Stem Cells · 2010 · 135 citations
    21. Isolation and Characterization of Cutaneous Epithelial Stem Cells Humana Press eBooks · 2013 · 4 citations
    22. Editorial: Hair Follicle Stem Cell Regeneration in Aging Frontiers in Cell and Developmental Biology · 2021 · 4 citations
    23. Stem Cells and their Niches Journal of Investigative Dermatology · 2013 · 1 citations
    24. Low fucosylation defines the glycocalyx of progenitor cells and melanocytes in the human limbal stem cell niche Stem Cell Reports · 2024 · 3 citations
    25. 701 Signaling networks between stem cell precursors, transit amplifying progenitors, and their niche in developing hair follicles Journal of Investigative Dermatology · 2016
    26. The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches Annual Review of Cell and Developmental Biology · 2016 · 42 citations
    27. Switching roles: the functional plasticity of adult tissue stem cells The EMBO Journal · 2015 · 87 citations
    28. Aged differentiated cells reverse into native stemness-like state by niche cytokines to sustain lifelong homeostasis and tissue repair Nature Communications · 2026
    29. Telogen Phase of Hair Growth Cycle Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Dermatological Science · 2012 · 1 citations
    30. Proteomics Characterization of Primary Human Oral Epithelial Cells Using a Novel Culture Technique for Use in Tissue Regeneration PubMed Central · 2015