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    Glossary Epidermal Differentiation

    process where skin cells mature to form protective barrier

    Epidermal differentiation is the process by which cells in the outermost layer of the skin, called the epidermis, mature and change to form a protective barrier. This involves the transformation of basal cells into specialized cells like keratinocytes, which produce keratin, a protein that helps protect the skin from environmental damage. This process is crucial for maintaining skin integrity and function.

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    1. Chapter 3 Expression and Modification of Keratins During Terminal Differentiation of Mammalian Epidermis 1987 · 81 citations
    2. Characterization of Mouse Profilaggrin: Evidence for Nuclear Engulfment and Translocation of the Profilaggrin B-Domain during Epidermal Differentiation 2002 · 25 citations
    3. Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs 2021 · 12 citations
    4. 169 TEDAR, a skin-specific long non-coding RNA, orchestrates the late epidermal differentiation program in the human epidermis Journal of Investigative Dermatology · 2025
    5. Epidermal Notch signalling: differentiation, cancer and adhesion Current opinion in cell biology · 2008 · 253 citations
    6. Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin Proceedings of the National Academy of Sciences · 2001 · 201 citations
    7. Lack of the Vitamin D Receptor is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth 2002 · 180 citations
    8. Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors Proceedings of the National Academy of Sciences of the United States of America · 2014 · 130 citations
    9. Overexpression of the calcium sensing receptor accelerates epidermal differentiation and permeability barrier formation in vivo Mechanisms of Development · 2003 · 46 citations
    10. Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets. PubMed · 2016 · 39 citations
    11. 591 Chromatin architectural protein CTCF regulates terminal keratinocyte differentiation in the developing epidermis and hair follicles 2021
    12. Basal cells in the epidermis and epidermal differentiation Research Square (Research Square) · 2021
    13. The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity Stem cell biology and regenerative medicine · 2018
    14. c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny Current Biology · 2001 · 338 citations
    15. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013 · 277 citations
    16. Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation The Journal of Cell Biology · 2001 · 195 citations
    17. 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis 2004 · 140 citations
    18. Epidermal differentiation: The role of proteases and their inhibitors European Journal of Cell Biology · 2004 · 118 citations
    19. Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation Molecular and cellular biology · 2002 · 108 citations
    20. Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex Journal of Investigative Dermatology · 2005 · 77 citations
    21. Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation EMBO journal · 2003 · 65 citations
    22. Impaired Hair Follicle Morphogenesis and Cycling with Abnormal Epidermal Differentiation in nackt Mice, a Cathepsin L-Deficient Mutation American Journal Of Pathology · 2002 · 57 citations
    23. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    24. Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13 -Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation 2015 · 16 citations
    25. Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature 2020 · 15 citations
    26. Isolation of Multipotent Nestin-Expressing Stem Cells Derived from the Epidermis of Elderly Humans and TAT-VHL Peptide-Mediated Neuronal Differentiation of These Cells International Journal of Molecular Sciences · 2013 · 12 citations
    27. Potential Role of the Epidermal Differentiation Complex in the Pathogenesis of Psoriasis Frontiers in Bioscience-Landmark · 2022 · 12 citations
    28. Autophagy-Mediated Cellular Remodeling during Terminal Differentiation of Keratinocytes in the Epidermis and Skin Appendages Cells · 2024 · 7 citations
    29. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    30. The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function 2013 · 1 citations