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    Glossary Keratinocyte Stem Cells

    specialized skin cells that regenerate and form keratinocytes

    Keratinocyte Stem Cells (KSCs) are specialized cells found in the basal layer of the epidermis, the outermost layer of the skin. These cells have the unique ability to self-renew and differentiate into keratinocytes, which are the primary cells that make up the skin, hair, and nails. KSCs play a crucial role in skin regeneration and wound healing, making them essential for maintaining healthy skin and repairing damage.

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    1. Epidermal keratinocyte stem cells: their maintenance and regulation Seminars in cell biology · 1992 · 25 citations
    2. Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin Journal of Visualized Experiments · 2016 · 23 citations
    3. Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin Journal of Visualized Experiments · 2016 · 13 citations
    4. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    5. SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis through p53/Stem Cell Factor/C-KIT Signaling Journal of Investigative Dermatology · 2024 · 4 citations
    6. Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation Journal of Dermatological Science · 2013 · 97 citations
    7. WIF1 Is Expressed by Stem Cells of the Human Interfollicular Epidermis and Acts to Suppress Keratinocyte Proliferation Journal of Investigative Dermatology · 2013 · 18 citations
    8. In-vivo dedifferentiation of keratinocytes to epidermal stem cells The Lancet · 2002 · 1 citations
    9. The CD44+ALDH+ Population of Human Keratinocytes Is Enriched for Epidermal Stem Cells with Long-Term Repopulating Ability Stem cells · 2013 · 28 citations
    10. 566 DermaCult™ Keratinocyte Expansion Medium, a Serum- and BPE-free Medium Supporting Long-term Feeder-free Expansion of Primary Human Epidermal and Pluripotent Stem Cell-Derived Keratinocytes Journal of Investigative Dermatology · 2022
    11. Two- and Three-Dimensional Culture of Keratinocyte Stem and Precursor Cells Derived from Primary Murine Epidermal Cultures Stem Cell Reviews and Reports · 2011 · 28 citations
    12. Optimisation of Culture Conditions for Expansion of Human Epidermal Stem Cells Journal of Health and Allied Sciences NU · 2026
    13. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage 2010 · 101 citations
    14. A Review: The Location, Molecular Characterisation and Multipotency of Hair Follicle Epidermal Stem Cells Annals of the Academy of Medicine Singapore · 2004 · 61 citations
    15. HPV8 Field Cancerization in a Transgenic Mouse Model Is due to Lrig1+ Keratinocyte Stem Cell Expansion Journal of Investigative Dermatology · 2017 · 25 citations
    16. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000 · 1010 citations
    17. Expansion of Hair Follicle Stem Cells Sticking to Isolated Sebaceous Glands to Generate in Vivo Epidermal Structures Cell Transplantation · 2016 · 10 citations
    18. Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in an in vitro wound model Frontiers in Medicine · 2025 · 8 citations
    19. Keratinocyte Stem Cells: Role in Aging IntechOpen eBooks · 2022 · 1 citations
    20. 25 Years of Epidermal Stem Cell Research Journal of Investigative Dermatology · 2012 · 55 citations
    21. Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging Aging Cell · 2020 · 23 citations
    22. Deriving Keratinocyte Progenitor Cells and Keratinocytes from Human‐Induced Pluripotent Stem Cells Current protocols in stem cell biology · 2020 · 10 citations
    23. Keratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis bioRxiv (Cold Spring Harbor Laboratory) · 2025
    24. 1418 Characterization of ectomesenchyme as an origin of epidermal stem cells Journal of Investigative Dermatology · 2023
    25. Analysis on the maintenance mechanisms of human interfollicular epidermal stem cell and their niche Journal of dermatological science · 2016
    26. Efficient expansion of human keratinocyte stem/progenitor cells carrying a transgene with lentiviral vector Stem Cell Research & Therapy · 2013 · 18 citations
    27. From basic biology to engineered therapies: the keratinocyte stem cell playbook Frontiers in Medical Technology · 2026
    28. Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment Stem cell research & therapy · 2021 · 14 citations
    29. Keratin K15 as a Biomarker of Epidermal Stem Cells International Journal of Molecular Sciences · 2013 · 85 citations
    30. Epidermal Stem Cells do not Communicate Through Gap Junctions Journal of Investigative Dermatology · 2002 · 73 citations