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    Glossary Epidermal Growth Factor Receptor

    protein on cell surfaces aiding growth and division

    The Epidermal Growth Factor Receptor (EGFR) is a protein found on the surface of cells that helps them grow and divide. It is crucial in regulating cell growth, survival, and differentiation. When EGFR is mutated or overexpressed, it can lead to uncontrolled cell proliferation, which is a common feature in various cancers.

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    1. Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice Experimental Dermatology · 2013 · 22 citations
    2. Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009 · 53 citations
    3. Cutaneous Lesions in the Rat Following Administration of an Irreversible Inhibitor of erbB Receptors, Including the Epidermal Growth Factor Receptor Toxicologic Pathology · 2008 · 21 citations
    4. The epidermal growth factor receptor decreases Stathmin 1 and triggers catagen entry in the mouse Experimental dermatology · 2015 · 10 citations
    5. Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. The EMBO Journal · 1995 · 252 citations
    6. Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor 2002 · 169 citations
    7. Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors European journal of cancer · 2007 · 138 citations
    8. The PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, and Dryness due to Epidermal growth factor receptor inhibitors) syndrome British Journal of Dermatology · 2006 · 90 citations
    9. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016 · 83 citations
    10. Epidermal Growth Factor Receptor Inhibitors: A Review of Cutaneous Adverse Events and Management Dermatology research and practice · 2014 · 68 citations
    11. 2,3,7,8‐Tetrachlorodibenzo‐<i>p</i>‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane Journal of Biochemical Toxicology · 1988 · 60 citations
    12. Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System Scientific Reports · 2020 · 58 citations
    13. Nonscarring inflammatory alopecia associated with the epidermal growth factor receptor inhibitor gefitinib Journal of the American Academy of Dermatology · 2006 · 57 citations
    14. Aberrant expression of epidermal growth factor receptor in aural cholesteatoma The Laryngoscope · 1993 · 48 citations
    15. Semiology of skin toxicity associated with epidermal growth factor receptor (EGFR) inhibitors Supportive Care in Cancer · 2012 · 38 citations
    16. A case report of inflammatory nonscarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib Journal of Cutaneous Pathology · 2009 · 33 citations
    17. Neutralization of IL-8 Prevents the Induction of Dermatologic Adverse Events Associated with the Inhibition of Epidermal Growth Factor Receptor PLoS ONE · 2012 · 32 citations
    18. Scarring alopecia associated with the epidermal growth factor receptor inhibitor erlotinib Journal of the American Academy of Dermatology · 2011 · 32 citations
    19. Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities Journal of the Formosan Medical Association · 2017 · 22 citations
    20. Role for the Epidermal Growth Factor Receptor in Chemotherapy-Induced Alopecia PLoS ONE · 2013 · 20 citations
    21. Treatment of Epidermal Growth Factor Receptor Inhibitor-Induced Acneiform Eruption with Topical Recombinant Human Epidermal Growth Factor Dermatology · 2012 · 19 citations
    22. Syntaxin 9 is Enriched in Skin Hair Follicle Epithelium and Interacts With the Epidermal Growth Factor Receptor Traffic · 2005 · 13 citations
    23. Histopathologic features of erythematous papulopustular eruption to epidermal growth factor receptor inhibitors in cancer patients Journal of Cutaneous Pathology · 2015 · 9 citations
    24. The trichoscopic features of hair shaft anomalies induced by epidermal growth factor receptor inhibitors: A case series Journal of the American Academy of Dermatology · 2020 · 7 citations
    25. Successful treatment of epidermal growth factor receptor inhibitor–induced alopecia with doxycycline JAAD Case Reports · 2015 · 6 citations
    26. A novel approach to manage skin toxicity caused by therapeutic agents targeting epidermal growth factor receptor Annals of oncology · 2012 · 4 citations
    27. Epidermal growth factor receptor/mitogen-activated kinase inhibitor treatment induces a distinct inflammatory hair follicle response that includes collapse of immune privilege British Journal of Dermatology · 2024 · 4 citations
    28. Epidermal growth factor receptor inhibitors and hair Journal of the American Academy of Dermatology · 2008 · 4 citations
    29. “Arrow” sign: A rapid microscopic diagnosis of hair change associated with epidermal growth factor receptor inhibitors Journal of the American Academy of Dermatology · 2013 · 3 citations
    30. Acneiform eruptions caused by an epidermal growth factor receptor-tyrosine kinase inhibitor ZD 1839 Journal of the American Academy of Dermatology · 2004 · 1 citations