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    Glossary Epidermal Differentiation Markers

    specific proteins indicating skin cell development stages

    Epidermal differentiation markers are specific proteins or molecules found in the skin that indicate the various stages of skin cell development and maturation. These markers help scientists and doctors understand how skin cells evolve from their initial form to their final, specialized state, which is crucial for maintaining healthy skin and diagnosing skin disorders.

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    1. LB1256 TRIV-509, a dual inhibitor of KLK5 and KLK7, rapidly improves barrier integrity and markers of epidermal differentiation in atopic dermatitis skin explants Journal of Investigative Dermatology · 2025
    2. LB1019 The early region of trichodysplasia spinulosa polyomavirus drives proliferation, altered differentiation, and ectopic expression of hair follicle differentiation markers in interfollicular tail epidermis 2022
    3. GATA3 inhibits proliferation and induces expression of both early and late differentiation markers in keratinocytes of the human epidermis Archives of Dermatological Research · 2013 · 24 citations
    4. Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs 2021 · 12 citations
    5. Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature 2020 · 15 citations
    6. 102 EZH2 is required for human hair follicle growth and epidermal differentiation Journal of Investigative Dermatology · 2016
    7. Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny during Cutaneous Wound Repair 2018 · 46 citations
    8. Neutrophil gelatinase‐associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin Experimental dermatology · 2002 · 96 citations
    9. Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin and the phorbol ester 12-<i>O</i>-tetradecanoylphorbol-13-acetate Carcinogenesis · 1987 · 12 citations
    10. Histochemical and Immunohistochemical Markers for Human Eccrine and Apocrine Sweat Glands: An Aid for Histopathologic Differentiation of Sweat Gland Tumors Journal of Investigative Dermatology Symposium Proceedings · 2001 · 73 citations
    11. Keratin expression in the normal nail unit: markers of regional differentiation British Journal of Dermatology · 2000 · 119 citations
    12. Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells Annals of the New York Academy of Sciences · 1991 · 31 citations
    13. FORMATION OF A REGULAR NEO-EPIDERMIS BY CULTURED HUMAN OUTER ROOT SHEATH CELLS GRAFTED ON NUDE MICE Transplantation · 1995 · 14 citations
    14. LB1077 Cutaneous responses to systemic iron: A potential role for epidermal turnover in mammalian iron excretion Journal of Investigative Dermatology · 2019
    15. LB1081 Three-dimensional imaging of tight junction-network across multiple layers of human epidermis by array tomography using backscattered electron-mode scanning electron microscopy Journal of Investigative Dermatology · 2019
    16. Regulation of epidermal proliferation and hair follicle cycling by synthetic photostable retinoid EC23 Journal of cosmetic dermatology · 2023
    17. Biochemistry of epidermal stem cells Biochimica et Biophysica Acta (BBA) - General Subjects · 2012 · 26 citations
    18. Epidermal keratinocyte stem cells: their maintenance and regulation Seminars in cell biology · 1992 · 25 citations
    19. 889 Trpv3 gain-of-function mutation impairs differentiation of hair follicle inner root sheath 2019
    20. Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis Journal of Investigative Dermatology · 2007 · 78 citations
    21. Transcriptomic landscape of early hair follicle and epidermal development Cell Reports · 2023 · 23 citations
    22. BMP2-mediated PTEN enhancement promotes differentiation of hair follicle stem cells by inducing autophagy Experimental cell research · 2019 · 24 citations
    23. Abstract 5219: The role of MEK and Antizyme in keratinocyte stem cell expansion and differentiation Cancer Research · 2012 · 1 citations
    24. A 4kb Fragment of the Desmocollin 3 Promoter Directs Reporter Gene Expression to Parakeratotic Epidermis and Primary Hair Follicles Journal of Investigative Dermatology · 2006 · 1 citations
    25. Transcriptomic landscape of early hair follicle and epidermal development bioRxiv (Cold Spring Harbor Laboratory) · 2022
    26. Involucrin: A Constituent of Cross-Linked Envelopes and Marker of Squamous Maturation 1986 · 23 citations
    27. Establishment of a new three‐dimensional human epidermal model reconstructed from plucked hair follicle‐derived keratinocytes Experimental Dermatology · 2016 · 12 citations
    28. 1360 Fate tracing of DNA-damaged hair follicle stem cells and their seno-differentiation clearance out of the niche 2023
    29. The relevance of collagen XVII expression in epidermal differentiation and proliferation Journal of dermatological science · 2016
    30. The changes in the expression levels of follicular markers in keratoacanthoma depend on the stage: keratoacanthoma is a follicular neoplasm exhibiting infundibular/isthmic differentiation without expression of CK15 Journal of Cutaneous Pathology · 2014 · 28 citations