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The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

The guidelines suggest lifestyle changes, diet adjustments, and personalized medication to manage dyslipidemia and reduce heart disease risk.

Corticosteroids, especially prednisone, improve short-term muscle strength in Duchenne muscular dystrophy but have manageable side effects.

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.

Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

The modified Ferriman-Gallwey method is a useful tool for diagnosing hirsutism.

Removing part of the vitamin D receptor stops vitamin D from working properly.

The document likely offers guidance on treating a woman's excessive hair growth, considering her symptoms and obesity.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.

Telogen effluvium is a reversible hair loss condition that requires a detailed diagnosis and often resolves on its own.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Laser hair removal is the most requested cosmetic procedure and has become a scientifically-based treatment suitable for all skin types.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.