28 citations
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July 2008 in “Developmental Biology” This study found that the loss of Smad4 in keratinocytes reduces Dsg4 expression via disrupted BMP signaling, contributing to hair follicle degeneration and alopecia.
8 citations
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June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study provides definitive evidence that a homozygous mutation in the DSC3 gene causes skin fragility and hypotrichosis in humans.
83 citations
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May 2011 in “European Journal of Dermatology” This review discusses the role of corneodesmosin in skin and hair follicle integrity, with mentions of its link to hypotrichosis simplex and peeling skin disease, and reports no new results.
August 2022 in “medRxiv (Cold Spring Harbor Laboratory)” This study found that certain medication clusters prescribed at hospital discharge are associated with different risks of adverse drug events in older adults, with respiratory cluster patients facing the highest risk.
This study reports various adverse effects associated with different doses and administration methods of a medical treatment, including gastrointestinal issues and hair loss, leading to modifications or discontinuations in some patients.
3 citations
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May 2015 in “Journal of The American Academy of Dermatology” Adalimumab significantly improves quality of life for patients with moderate to severe hidradenitis suppurativa.
April 2017 in “Journal of Investigative Dermatology” In laboratory tests and mouse models, this study found that the novel IPC analog SIG-1451 may offer potent anti-inflammatory effects for treating allergic skin inflammation, potentially outperforming some current therapies in specific inflammatory phases.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that an E-cadherin mutant preserved normal cadherin levels and prevented inflammation and lethality in mouse skin lacking p120, highlighting p120's role in regulating cadherin-mediated cell adhesion and inflammation.
March 2026 in “Acta Dermato Venereologica” This study found that dermatology patients with tattoos or piercings may have a higher risk of body dysmorphic disorder tendencies and lower acceptance of their illness.
4 citations
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December 2024 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft” In this retrospective cohort study, researchers found that Taiwanese mothers with atopic dermatitis had a higher risk of various pregnancy complications and that their children were more likely to develop certain conditions like AD, asthma, and ADHD, compared to non-AD mothers and their children.
August 2025 in “Psychiatry Neurology and Medical Psychology” This study investigated psychosocial adaptation in women with diffuse alopecia, finding that adaptation disorders, particularly related to depression and anxiety, more significantly impacted psychosocial adaptation than the alopecia's origin, highlighting areas for targeted psychological intervention.
2 citations
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August 2012 in “Journal of the American Academy of Dermatology” This correspondence describes two patients with both epidermolysis bullosa simplex, Dowling-Meara type, and loose anagen hair syndrome, an association not previously reported in the literature.
August 2026 in “JAMA Dermatology” This study found that upadacitinib significantly improved hair regrowth compared to placebo in adults and adolescents with severe alopecia areata, and demonstrated a positive benefit-risk profile.
1 citations
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September 2016 in “Journal of Dermatological Science” In this study using tamoxifen-inducible claudin-1 knockout mice, researchers observed that tight junction barrier leakage induced stratum corneum barrier defects and skin inflammation, suggesting a possible cycle of barrier damage and inflammation in atopic dermatitis.
In this study conducted at an Egyptian outpatient clinic, researchers found that systemic lupus erythematosus patients who were non-adherent to medication had a higher rate of hospitalization and more clinical symptoms compared to those who adhered to their prescribed treatments.
29 citations
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July 2012 in “The Journal of Sexual Medicine” In this study using a rat model, discontinuing dutasteride improved some relaxant responses but did not fully restore erectile function, indicating a potential time-dependent detriment of the drug.
October 2022 in “JAAD international” This study found that more than 70% of patients with autoimmune blistering diseases experienced alopecia, with about 10% having scarring alopecia, and elevated Dsg1 ratios were linked to hair loss in pemphigus vulgaris.
59 citations
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January 2002 in “Dermatology” This study suggests the existence of a new subtype of alopecia, called 'acute diffuse and total alopecia of the female scalp (ADTAFS)', characterized by acute, diffuse hair loss primarily in women and a rapid recovery.
April 2016 in “The Journal of Sexual Medicine” This report analyzed an FDA adverse event database and aimed to evaluate and describe post-finasteride syndrome potentially related to dutasteride, but it does not report new clinical findings.
4 citations
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October 2021 in “Journal of Clinical Medicine” This study found that individuals with heterozygous truncation-type variants in the *DSP* gene exhibit lower skin temperature and higher transepidermal water loss, with specific microscopic skin changes and pseudomonilethrix.
17 citations
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December 2018 in “The World Journal of Men s Health” This study concluded that administering dutasteride for more than 8 weeks in rats could lead to irreversible erectile dysfunction, even after stopping the medication.
2 citations
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September 2018 in “Clinical and Experimental Dermatology” This study found that pemphigus-associated alopecia indicates severe and treatment-resistant pemphigus, with higher disease activity and antibody levels compared to patients without alopecia.
February 2026 in “PubMed” In this study, adult male rats exhibited significant anxiety-like behaviors following finasteride withdrawal, including pronounced hyperactivity and novelty avoidance, highlighting potential parallels with post-finasteride syndrome observed in clinical settings.
1 citations
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April 2023 in “International journal of molecular sciences” In this study, AMACO was found to be non-essential for the formation or function of anchoring cords in mice, despite its presence in the structure.
May 2025 in “International Journal of Science and Research (IJSR)” In this case report, azathioprine induced sudden hair loss and pancytopenia in a 42-year-old female patient, but discontinuing the drug and providing supportive care resulted in complete recovery and hair regrowth within 2.5 months.
1 citations
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July 1991 in “PubMed” This case report describes a patient with adrenomyeloneuropathy, highlighting unusual MRI findings of high signal areas in the right striatum.
20 citations
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February 2004 in “Clinical & Experimental Immunology” This study suggests that long-term treatment with the contact sensitizer SADBE in mice may reduce leucocyte traffic in alopecia areata through impaired leucocyte extravasation.
42 citations
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January 2009 in “Colloids and Surfaces B: Biointerfaces” This study found that dimethylpabamidopropyl laurdimonium tosylate, a quaternary ammonium surfactant, adsorbs onto human scalp hair with kinetic and isotherm behaviors fitting specific models, changing hair fiber wettability from hydrophobic to hydrophilic.
April 2023 in “Journal of Investigative Dermatology” In this study, researchers developed a mouse model of scarring alopecia and observed significant reductions in CD200R expression in affected skin, potentially linking this signaling pathway to immune attacks on hair follicles and suggesting new treatment targets for scarring hair loss.
7 citations
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August 2024 in “Clinical and Experimental Dermatology” In this retrospective study conducted at a trichology clinic, the off-label use of upadacitinib for at least 24 weeks was found to have a promising efficacy and safety profile for treating severe alopecia areata in adolescents.