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Glossary Derminator 2

The Derminator 2 is a microneedling device designed to promote hair growth and improve scalp health by creating micro-injuries in the skin. This process stimulates the body's natural healing response, which can enhance blood circulation and increase the absorption of topical treatments for hair loss. Its relevance to hair biology lies in its ability to potentially activate dormant hair follicles and improve the overall condition of the scalp, making it a popular choice among individuals seeking non-invasive hair restoration methods. Key distinguishing characteristics include its adjustable needle depth and speed settings, allowing for personalized treatment based on individual needs.

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research An incompletely penetrant novel MAFB (p.Ser56Phe) variant in autosomal dominant multicentric carpotarsal osteolysis syndrome

20 citations , May 2013 in “International Journal of Molecular Medicine”

This study identified a novel missense MAFB variant in a family with some unaffected members, suggesting incomplete penetrance and the potential influence of modifier genes, epigenetic mechanisms, or environmental factors on MCTO phenotype.

research A retrospective analysis of efficacy and safety of intralesional triamcinolone injections in the treatment of frontal fibrosing alopecia either as monotherapy or as a concomitant therapy

13 citations , January 2018 in “International Journal of Trichology”

In this study, intralesional triamcinolone acetonide injections were associated with halting the progression of frontal fibrosing alopecia in female patients and showed minimal adverse effects, but the efficacy as sole therapy remains unclear pending further trials.

research Selection criteria and techniques for improved cosmesis and predictable outcomes in laser hair removal treatment of acne keloidalis nuchae

9 citations , June 2019 in “JAAD case reports”

This report discusses laser hair removal for acne keloidalis nuchae, noting generally favorable outcomes but variability in lesion responsiveness and a need for standardized assessment criteria; it reports no new results.

research Is the Loose Anagen Hair Syndrome a Keratin Disorder?

84 citations , April 2002 in “Archives of Dermatology”

This study found that a keratin mutation may cause diffuse partial woolly hair associated with loose anagen hair syndrome in some families, but other genetic factors could play a role in different cases.

research Identification of a Rare Variant in the SRD5A2 Gene in Siblings With 46,XY Disorders of Sexual Development

January 2025 in “Case Reports in Genetics”

The researchers identified a pathogenic variant in the SRD5A2 gene among siblings with 46,XY disorder of sexual development, highlighting the importance of comprehensive genetic testing in diagnosis and management.

research Prevalence and accurate diagnosis of polycystic ovary syndrome in adolescents across world regions: a systematic review and meta-analysis

40 citations , September 2024 in “European Journal of Endocrinology”

This study found that global PCOS prevalence in adolescents is 6.3% under new 2023 guideline criteria, compared to 9.8% using Rotterdam criteria; excluding PCOM may prevent over-diagnosis, while recognizing irregular cycles or hyperandrogenism helps avoid under-diagnosis by identifying at-risk individuals for further monitoring.

research Two-ligand priming mechanism for potentiated phosphoinositide synthesis is an evolutionarily conserved feature of Sec14-like phosphatidylinositol and phosphatidylcholine exchange proteins

25 citations , May 2016 in “Molecular biology of the cell”

This study found that the AtSfh1 protein in Arabidopsis is essential for phosphatidylinositol-4,5-bisphosphate signaling crucial to polarized root hair growth, utilizing both phosphatidylinositol and phosphatidylcholine-binding activities.

research A quantitative technique to analyze and evaluate microstructures of skin hair follicles based on mueller matrix polarimetry

9 citations , September 2022 in “Frontiers in Physics”

This study found that Mueller Matrix microscopy can accurately identify, detect, and evaluate hair follicles in mouse skin tissue, suggesting its potential for skin structure research and dermatological applications.

research Pharmacology and Pharmacokinetics of Minoxidil

57 citations , January 1980 in “Journal of Cardiovascular Pharmacology”

Minoxidil treats high blood pressure and side effects can be managed.

research Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice

53 citations , October 2014 in “Free radical biology & medicine”

This study found that oxidative damage is present in the mitochondria of PolG mice, which exhibit premature aging-like phenotypes due to mitochondrial dysfunction.

research FDA Reports of Alopecia as an Adverse Event to Isotretinoin

5 citations , July 2019 in “Journal of Cutaneous Medicine and Surgery”

Isotretinoin may cause hair loss, especially in women and young adults.

Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

1744 citations , August 2006 in “The Journal of Clinical Endocrinology and Metabolism”

This review discusses definitions of polycystic ovary syndrome and reports no new clinical results; the authors support using modified 1990 NIH criteria and acknowledge ongoing evolution as research advances.

research The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report

1540 citations , October 2008 in “Fertility and Sterility”

This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.

research Regeneration of fat cells from myofibroblasts during wound healing

408 citations , January 2017 in “Science”

This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.

WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

research WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes

197 citations , June 2009 in “American journal of human genetics”

This study found that previously undescribed WNT10A mutations are a prominent cause of various forms of ectodermal dysplasia, including OODD and Schöpf-Schulz-Passarge syndrome, with gender-specific phenotypic effects noted.

research Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss

116 citations , September 2001 in “Journal of The American Academy of Dermatology”

This study suggests that miniaturization in pattern hair loss may occur abruptly and can be reversed with treatment, as supported by histologic evidence in finasteride-responsive patients.

research Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase

73 citations , June 2010 in “PLoS Genetics”

This study identified that a deficiency in the palmitoyl transferase enzyme, due to a mutation in the Zdhhc13 gene, led to severe physiological abnormalities in mice, including skin, bone, and systemic amyloid issues.

Frontal Fibrosing Alopecia: Reflections and Hypotheses on Etiology and Pathogenesis

research Frontal fibrosing alopecia: reflections and hypotheses on aetiology and pathogenesis

68 citations , May 2016 in “Experimental dermatology”

This review discusses what is known about the pathobiology of frontal fibrosing alopecia and reports no new clinical findings, highlighting potential environmental and genetic factors in disease pathogenesis.

research Two Hypomorphic Alleles of Mouse Ass1 as a New Animal Model of Citrullinemia Type I and Other Hyperammonemic Syndromes

35 citations , August 2010 in “The American journal of pathology”

This study reports that hypomorphic alleles of the Ass1 gene in mice resemble human CTLN1, providing a potential model for preclinical studies and indicating that standard treatments for CTLN1 can rescue phenotypes.

research NovelPAX9mutation associated with syndromic tooth agenesis

20 citations , July 2013 in “European Journal of Oral Sciences”

This study found a novel PAX9 gene mutation that may cause tooth agenesis and trichodysplasia in a studied family.

research Fluridil, a Rationally Designed Topical Agent for Androgenetic Alopecia: First Clinical Experience

17 citations , August 2002 in “Dermatologic Surgery”

This study found that topical fluridil increased the anagen hair percentage in men with androgenetic alopecia without causing irritation or systemic absorption over 9 months.

Cutaneous Drug Eruptions Associated with the Use of Biologics and Cutaneous Drug Eruptions Mimicking Specific Skin Diseases

research Cutaneous Drug Eruptions Associated with the Use of Biologies and Cutaneous Drug Eruptions Mimicking Specific Skin Diseases

4 citations , January 2012 in “Chemical Immunology”

This paper discusses the challenges of diagnosing drug eruptions, emphasizing the nonspecific patterns and unclear pathomechanisms, and calls for further research using new biologic drugs to understand these reactions better.

research Trelles-Jaeger Lid Plate

1 citations , January 2001 in “Dermatologic Surgery”

Pulsed dye laser and hydrogel dressings effectively treat hypertrophic scars.

research Letters to the Editor

January 2001 in “Dermatologic Surgery”

The letters discussed medical tools, costs, treatment efficacy, and patient care complexities.

research Molecular and Pathological Studies on Sarcoptes scabiei in Sheep in Ismailia Province, Egypt.

August 2020 in “Egyptian Veterinary Medical Society of Parasitology Journal (EVMSPJ)”

In this study, 10.5% of sheep examined in Ismailia, Egypt, were infested with Sarcoptes scabiei, showing specific molecular and skin alterations.

research The Mathematics of Hair Restoration Surgery

February 1997 in “Dermatologic Surgery”

This review discusses mathematical correlations in hair restoration surgery but reports no new research findings.

research Fluridil, a Rationally Designed Topical Agent for Androgenetic Alopecia

August 2002 in “Dermatologic Surgery”

This study found that topical fluridil increased the anagen percentage in men with androgenetic alopecia without causing irritation or systemic side effects.

research Overweight and Obesity in Children and Adolescents

356 citations , September 2014 in “Journal of Clinical Research in Pediatric Endocrinology”

This article discusses the rising prevalence and serious implications of childhood obesity and reports no new experimental findings; the authors emphasize the importance of prevention and early intervention through comprehensive management programs.

research The Rotterdam Study: 2016 objectives and design update

336 citations , August 2015 in “European Journal of Epidemiology”

This article reviews the design and objectives of the Rotterdam Study, as well as summarizes major findings, without reporting new results.

research Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

271 citations , September 2008 in “Nutrition reviews”

This study identified new dietary ligands for the human vitamin D receptor, including curcumin and gamma-tocotrienol, which may influence its biological functions.