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    Glossary Dermal Sheath

    layer of connective tissue surrounding and supporting hair follicle

    The dermal sheath is a layer of connective tissue that surrounds the hair follicle, providing structural support and playing a role in hair growth and regeneration. It contains cells that can influence the behavior of the hair follicle, making it important in studies of hair loss and treatments for conditions like alopecia.

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    1. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014 · 184 citations
    2. Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells Development · 1996 · 61 citations
    3. Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype Frontiers in Genetics · 2022 · 37 citations
    4. Human hair follicle dermal papilla cell, dermal sheath cell and interstitial dermal fibroblast characteristics. PubMed · 1996 · 36 citations
    5. Autologous cell–based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study Journal of The American Academy of Dermatology · 2020 · 22 citations
    6. Characterization of human dermal sheath cells reveals CD36-expressing perivascular cells associated with capillary blood vessel formation in hair follicles Biochemical and Biophysical Research Communications · 2019 · 16 citations
    7. Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species European Journal of Histochemistry · 2009 · 15 citations
    8. Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles Acta dermato-venereologica · 2018 · 11 citations
    9. Dermal sheath cells contribute to postnatal hair follicle growth and cycling Journal of Dermatological Science · 2016 · 10 citations
    10. Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts Archives of Dermatological Research · 2005 · 9 citations
    11. Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species European journal of histochemistry · 2009 · 6 citations
    12. Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression Nature cell biology · 2023 · 5 citations
    13. Hair-follicle dermal papilla and sheath fibroblasts provide a supportive microenvironment for human skin regeneration 2017 · 3 citations
    14. Establishment of dermal sheath cell line from Cashmere goat and characterizing cytokeratin 13 as its novel biomarker Biotechnology Letters · 2018 · 2 citations
    15. Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair Advances in Wound Care · 2025 · 1 citations
    16. Exploring the Role of Dermal Sheath Cells in Wound Healing and Fibrosis Preprints.org · 2024 · 1 citations
    17. Staining of human skin with RGB trichrome unveils a proteoglycan-enriched zone in the hair dermal sheath bioRxiv (Cold Spring Harbor Laboratory) · 2022
    18. Faculty Opinions recommendation of Age-related changes in female scalp dermal sheath and dermal fibroblasts: how the hair follicle environment impacts hair ageing. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2021
    19. Faculty Opinions recommendation of Dermal sheath contraction powers stem cell niche relocation during hair cycle regression. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2020
    20. 022 Randomized, double-blind, placebo-controlled, single-centre, phase I safety study of intradermal injections of autologous fibroblasts isolated from the non-bulbar dermal sheath of the hair follicle to treat skin aging Journal of Investigative Dermatology · 2017
    21. Differential Expression of CXCL12 in Human and Mouse Hair: Androgens Induce CXCL12 in Human Dermal Papilla and Dermal Sheath Cup International Journal of Molecular Sciences · 2024
    22. 259 Scalp hair follicle dermal sheath fibroblasts express genes associated with promotion of skin integrity/wound healing and prevention of autoimmune responses in Recessive Dystrophic Epidermolysis Bullosa Journal of Investigative Dermatology · 2024
    23. Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells Experimental Dermatology · 2023
    24. High migratory activity of dermal sheath cup cells associated with the clinical efficacy of autologous cell-based therapy for pattern hair loss Journal of Dermatological Science · 2023
    25. Efficacy of autologous dermal sheath cup cell transplantation in male and female pattern hair loss: A Single‐Arm, Multi‐Center, phase III equivalent clinical study The Journal of Dermatology · 2023
    26. The Growth of Human Dermal Papilla Cells and Dermal Sheath Cells in Vitro Chinese Journal of Dermatology · 2001
    27. Growth kinetics of cultured dermal papilla cells and dermal sheath cells from human hair follicles Acta Academiae Medicine Militaris Tertiae · 2000
    28. 602 Efficacy of autologous cell-based therapy for male and female pattern hair loss using dermal sheath cup cells: A single arm, multi-center, confirmatory clinical study Journal of Investigative Dermatology · 2023
    29. Dermal Sheath Cells and Hair Follicle Regeneration Stem cell biology and regenerative medicine · 2022
    30. Sex Hormones and Antiandro Growth of Dermal Papilla H ens Influence In Vitro Ce Is and Outer Root Sheath Keratinocytes of Human Hair Follicles 1993