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    Glossary Dermal Papilla Cell Exosomes

    tiny vesicles from hair follicle cells that promote hair growth

    Dermal Papilla Cell Exosomes (DPC-Exos) are tiny vesicles secreted by dermal papilla cells, which are specialized cells located at the base of hair follicles. These exosomes play a crucial role in hair growth and regeneration by transferring proteins, lipids, and genetic material to surrounding cells, thereby promoting cellular communication and stimulating hair follicle activity.

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    1. Dermal papilla cell-derived exosomes promote hair follicle regeneration during wound healing by activating Wnt/β‐catenin signaling pathway Research Square (Research Square) · 2024
    2. The effect of adipose-derived stem cell exosomes on the biological activity of dermal papilla cells DOAJ (DOAJ: Directory of Open Access Journals) · 2022
    3. Decorin-mediated dermal papilla cell-derived exosomes regulate hair follicle growth and development through miR-129-2-3p/SMAD3/TGF-β axis International Journal of Biological Macromolecules · 2025
    4. Exosomes Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation through the Wnt3a/β-Catenin Signaling Pathway Oxidative Medicine and Cellular Longevity · 2022 · 2 citations
    5. Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cell Tissue Engineering and Regenerative Medicine · 2020 · 9 citations
    6. 1362 Dermal papilla cell-derived extracellular vesicles as the future tools for hair regeneration 2023
    7. Dermal PapillaCell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1 International Journal of Molecular Sciences · 2023
    8. hUC-MSC-exosomes deliver Let-7b/7f-5p to dermal papilla cells for a multi-target synergistic treatment of androgenetic alopecia Journal of Nanobiotechnology · 2026
    9. Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation International journal of biological sciences · 2019 · 71 citations
    10. Iris germanica L. Rhizome-Derived Exosomes Ameliorated Dihydrotestosterone-Damaged Human Follicle Dermal Papilla Cells Through the Activation of Wnt/β-Catenin Pathway International Journal of Molecular Sciences · 2025
    11. Potential of mesenchymal stem cell-derived exosomes in the treatment of androgenetic alopecia World Journal of Stem Cells · 2025
    12. Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway International Journal of Molecular Sciences · 2023
    13. Exploring the Potential of Mesenchymal Stem Cell–Derived Exosomes for the Treatment of Alopecia Regenerative Engineering and Translational Medicine · 2021 · 12 citations
    14. Novel Strategy for Hair Regeneration: Exosomes and Collagenous Sequences of Human a1(XVII) Chain Enhance Hair Follicle Stem Cell Activity by Regulating the hsa-novel-238a-CASP9 Axis Experimental Cell Research · 2025
    15. Rose stem cell‐derived exosomes for hair regeneration enhancement via noninvasive electroporation in androgenetic alopecia Journal of Cosmetic Dermatology · 2024
    16. Mesenchymal stem cell-derived exosomes promote scalp rejuvenation through type XVII collagen regulation via the miR-21-5p/DKK2/Wnt pathway Frontiers in Cell and Developmental Biology · 2026
    17. 21 Adipose stem cell exosome (ASCE): next generation regenerative aesthetics & therapeutics for scalp & hair Journal of Investigative Dermatology · 2023
    18. 1615 Adipose stem cell exosome (ASCE): Next generation regenerative aesthetics & therapeutics for scalp & hair Journal of Investigative Dermatology · 2023
    19. Dental pulp stem cell exosomes promote angiogenesis via the PI3K/Akt signaling pathway to treat androgenetic alopecia Stem Cell Research & Therapy · 2026
    20. Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway Stem Cell Research & Therapy · 2025
    21. Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/β-Catenin Pathway Stem Cells International · 2023
    22. Dermal Papilla Cells: From Basic Research to Translational Applications Biology · 2024
    23. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020 · 35 citations
    24. Effects of Exosomes Derived from Dermal Papilla Cells on Hair Follicle Stem Cells and Hair Follicle Organoids Yokohama National University Repository (Yokohama National University) · 2022
    25. The efficacy of adipose stem cell‐derived exosomes in hair regeneration based on a preclinical and clinical study International Journal of Dermatology · 2024 · 2 citations
    26. Mir-574-3p and Mir-125a-5p in Adipose Derived Mesenchymal Stem Cell Exosomes Synergistically Target TGF-β1/Smad2 Signaling Pathway for the Treatment of Androgenic Alopecia Journal of Investigative Dermatology · 2025
    27. Regulation of hair follicle development by exosomes derived from dermal papilla cells Biochemical and Biophysical Research Communications · 2018 · 87 citations
    28. Harnessing miRNA Milk-Derived Exosomes for Hair Loss Disorders: In Vitro Modulation of WNT Signaling and Dermal Papilla Proliferation Cosmetics · 2026
    29. Exosomes derived from dermal papilla cells mediate hair follicle stem cells proliferation through the Wnt3a/β-catenin signaling pathway Figshare · 2022
    30. UC-MSC-Es enhance the proliferation of human hair dermal papilla cells. Figshare · 2025