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    Glossary Cytochrome P450

    enzymes metabolize drugs and toxins in the liver

    Cytochrome P450 (CYP) refers to a large family of enzymes that play a crucial role in the metabolism of various substances within the body, including drugs, toxins, and hormones. These enzymes are primarily found in the liver and are essential for the detoxification process, as well as the synthesis of cholesterol, steroids, and other lipids.

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    1. Testosterone, cytochrome P450, and cardiac hypertrophy The FASEB Journal · 2002 · 155 citations
    2. Cytochrome P450: A Target for Drug Development for Skin Diseases 2004 · 115 citations
    3. Comparison of Activities Dependent on Glutathione S-Transferase and Cytochrome P-450 IA1 in Cultured Keratinocytes and Reconstructed Epidermal Models Skin Pharmacology and Physiology · 2002 · 42 citations
    4. Immunohistochemical detection of cytochrome P450 isoenzymes in cultured human epidermal cells. Journal of Histochemistry & Cytochemistry · 1990 · 19 citations
    5. Identification of a Cyclosporine-Specific P450 Hydroxylase Gene through Targeted Cytochrome P450 Complement (CYPome) Disruption in Sebekia benihana Applied and Environmental Microbiology · 2013 · 13 citations
    6. Transcriptome sequencing and identification of cytochrome P450 monooxygenases involved in the biosynthesis of maslinic acid and corosolic acid in <i>Avicennia marina</i> Plant Biotechnology · 2018 · 10 citations
    7. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro The Journal of Steroid Biochemistry and Molecular Biology · 2019 · 7 citations
    8. Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1 Frontiers in Pharmacology · 2022 · 1 citations
    9. Identification of Potential Cytochrome p450c 17 Alpha Inhibitors for the Treatment of PCOS via Scaffold Hopping and Fragment-Based De-Novo Drug Design 2024
    10. The Role of Cytochrome P-450 in Dermatology International Journal of Dermatology · 1989 · 8 citations
    11. Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride. PubMed · 1995 · 20 citations
    12. Eziopatogenesi e terapia dell'acne:studio epidemiologico delle caratteristiche cliniche di una popolazione di pazienti affetti da acne e analisi dei polimorfismi del gene codificante per il recettore degli androgeni e del gene codificante per il citocromo P-450 1A1 Padua Research Archive (University of Padua) · 2008
    13. Skin Cancer: Mechanisms and Human Relevance Medical Entomology and Zoology · 1994 · 213 citations
    14. Baiting Proteins with C<sub>60</sub> ACS Nano · 2010 · 106 citations
    15. Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α Journal of Neuroendocrinology · 2011 · 52 citations
    16. Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models Archives of Toxicology · 2018 · 38 citations
    17. Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient Acta pædiatrica · 2002 · 37 citations
    18. Successful treatment of female-pattern hair loss with spironolactone in a 9-year-old girl Australasian Journal of Dermatology · 2009 · 26 citations
    19. Detection of urine metabolites in polycystic ovary syndrome by UPLC triple-TOF-MS Clinica Chimica Acta · 2015 · 23 citations
    20. Clinically-Relevant Chemotherapy Interactions with Complementary and Alternative Medicines in Patients with Cancer Recent patents on food, nutrition & agriculture · 2010 · 15 citations
    21. Hydroxylation of dehydroepiandrosterone in human scalp hair folhcles British Journal of Dermatology · 1979 · 11 citations
    22. Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient Acta pædiatrica · 2002 · 6 citations
    23. Functional characterization and unraveling the structural determinants of novel steroid hydroxylase CYP154C7 from Streptomyces sp. PAMC26508 Heliyon · 2024 · 4 citations
    24. A novel regio-specific cyclosporin hydroxylase gene revealed through the genome mining of <i>Pseudonocardia autotrophica</i> Journal of Industrial Microbiology & Biotechnology · 2014 · 3 citations
    25. Hepato- and neuro-toxicity by ethylenthiourea. PubMed · 1985 · 2 citations
    26. Response to “Reply to effectiveness of dutasteride in a large series of patients with FFA in real clinical practice” 2021 · 2 citations
    27. Chapter 14 Principles of drug metabolism Principles of Medical Biology · 1997 · 2 citations
    28. Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4′-OH)MeLeu]4-CsA overproduction Microbial Cell Factories · 2017 · 1 citations
    29. Disruptors of Androgen Action and Synthesis Elsevier eBooks · 2015 · 1 citations
    30. Iatrogenic Cushing Syndrome and Secondary Adrenal Insufficiency Due to an Interaction Between Fluticasone and Ritonavir Journal of the Endocrine Society · 2021 · 1 citations