352 citations
,
January 2006 in “The Journal of Clinical Endocrinology and Metabolism” This study reported that classic anovulatory PCOS was the most common androgen excess disorder, followed by mild ovulatory PCOS and idiopathic hyperandrogenism, among patients evaluated for clinical hyperandrogenism.
249 citations
,
November 2003 in “Clinical endocrinology” This review discusses the complex etiology of polycystic ovary syndrome (PCOS), highlighting its association with insulin resistance and hyperandrogenism, but reports no clinical findings; the authors suggest further investigation of the pathophysiological mechanisms.
222 citations
,
January 2014 in “International journal of reproductive medicine” This paper reviews the complex pathophysiology of polycystic ovary syndrome, exploring how hormonal and metabolic disturbances contribute to its symptoms and related health risks, but it presents no new findings.
150 citations
,
November 2007 in “The Journal of Clinical Endocrinology and Metabolism” This study determined that nonclassical congenital adrenal hyperplasia has a 2.2% prevalence among hyperandrogenic women in Spain, with basal serum 17-hydroxyprogesterone showing excellent diagnostic performance.
115 citations
,
January 2001 in “American journal of clinical dermatology” This study found that eflornithine 15% cream reduced unwanted facial hair growth more effectively than a placebo in women with hirsutism, but hair growth returned to pretreatment levels within 8 weeks of stopping treatment.
114 citations
,
December 1951 in “Archives of Dermatology” This article reviews the effectiveness of adrenal cortex compounds E and F in treating various connective tissue disorders and reports no new clinical findings.
100 citations
,
September 2016 in “Clinical transplantation/Clinical transplantation.” This study highlights that prolonged voriconazole use is linked to an increased risk of aggressive cutaneous malignancies like squamous cell carcinoma, necessitating careful monitoring of drug levels to manage adverse effects.
99 citations
,
August 2003 in “Fertility and Sterility” This paper discusses polycystic ovary syndrome with a focus on androgen excess as the primary symptom and notes that insulin resistance may contribute to it in many patients, but provides no new research findings.
97 citations
,
February 2007 in “Clinical Obstetrics and Gynecology” This article reviews the diagnostic criteria and prevalence of PCOS, emphasizing its status as the most common endocrine disorder among women of reproductive age, with no new clinical results reported.
97 citations
,
July 2006 in “Dermatologic therapy” This article reviews the diagnosis and treatment approaches for cutaneous manifestations of PCOS, reporting on various treatment options without presenting new clinical results.
94 citations
,
April 2002 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study describes the first case of female pseudohermaphroditism due to a novel homozygous glucocorticoid receptor gene mutation, indicating possible pre- and postnatal virilization in affected females.
70 citations
,
March 2010 in “The Journal of Steroid Biochemistry and Molecular Biology” This study discusses the potential of targeting 11β-HSD1 for treating metabolic syndrome and highlights emerging promising data from human trials on selective 11β-HSD1 inhibitors.
69 citations
,
December 2005 in “Nature Clinical Practice Endocrinology & Metabolism” Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.
66 citations
,
September 2008 in “Dermatologic therapy” This review discusses medical treatments for hirsutism, focusing on oral contraceptives and other therapies, but reports no new results; the authors emphasize the lack of evidence for insulin sensitizers in treating hirsutism alone.
60 citations
,
March 2014 in “Veterinary dermatology” This study reported that the prevalence of atopic dermatitis in cats was higher than previously suggested, with severe nonseasonal pruritus most common, and certain breeds were predisposed.
57 citations
,
January 1995 in “The American journal of medicine” This study discusses the use of oral contraceptives as a treatment for hyperandrogenism, showing improvement in hirsutism and acne for many women and possibly providing metabolic benefits with certain formulations.
54 citations
,
October 2019 in “Australian Journal of General Practice” This article provides an updated overview of the diagnosis and management of tinea infections but reports no new clinical findings.
52 citations
,
October 2004 in “Veterinary dermatology” This study found that 62% of neutered dogs with hair cycle arrest experienced partial to complete hair re-growth after melatonin treatment, but hair re-growth was not consistently linked to normal sex hormone levels.
48 citations
,
March 1997 in “Veterinary Dermatology” This report describes a paraneoplastic alopecia in four cats associated with internal malignancy, confirming previous findings of a syndrome linking ventral alopecia and metastatic carcinomas.
47 citations
,
March 2004 in “European journal of endocrinology” This study found that the combination of spironolactone and finasteride significantly improved hirsutism scores more than spironolactone alone in women, with similar side-effect profiles between treatments.
46 citations
,
September 2011 in “Journal of Endocrinology” This study suggests that 5α-reduced glucocorticoids may have anti-inflammatory potential and could serve as biomarkers for liver inflammation in metabolic disease, with implications for drug development.
46 citations
,
August 1990 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” In this study, ketoconazole treatment improved acne in all women and reduced hirsutism in some, but it caused several side effects and requires careful monitoring.
44 citations
,
June 1985 in “Fertility and sterility” This study suggests that combination drug therapy with spironolactone and either oral contraceptives or dexamethasone effectively manages unresponsive hirsutism, with eight of nine patients achieving satisfactory clinical responses.
43 citations
,
August 2010 in “Expert Opinion on Investigational Drugs” This review explores the potential of selective 11β-HSD1 inhibitors to improve insulin sensitivity in type 2 diabetes, emphasizing the need for more clinical research and reports no new clinical results.
43 citations
,
May 1988 in “British Journal of Dermatology” This study reported that patients with acanthosis nigricans and insulin resistance exhibited higher insulin levels and were associated with increased insulin resistance correlating with serum testosterone levels.
42 citations
,
January 2011 in “European Journal of Dermatology” In this study, higher scores of HOMA-IR and FIRI suggested that male patients with early-onset androgenetic alopecia may have insulin resistance, although no significant differences in metabolic syndrome were found compared to controls.
39 citations
,
May 2011 in “European Journal of Clinical Investigation” This review discusses the various causes of hirsutism other than PCOS, emphasizing the importance of distinguishing potentially life-threatening conditions like androgen-secreting tumors from more benign causes; it reports no new clinical findings.
37 citations
,
August 2012 in “European Journal of Obstetrics & Gynecology and Reproductive Biology” In this study, a modified Ferriman-Galwey score greater than 4 was found to be effective for diagnosing hirsutism in Asian women, highlighting key areas such as the upper lip, thighs, and lower abdomen.
37 citations
,
January 2004 in “Hormone Research in Paediatrics” In this study, the prevalence of clinical polycystic ovary syndrome among high school girls in Isfahan, Iran was reported at 3%, with a note that hormonal assessments might uncover higher rates.
36 citations
,
January 2017 in “Journal of Obstetrics and Gynaecology Research” This review discusses the association between vitamin D receptor polymorphisms and polycystic ovary syndrome, noting the need for further research on their impact on the disorder's manifestations.