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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Oral estradiol works for many transgender women but needs personalized dosing and monitoring.

The transgender community in India has specific skin care needs and struggles to access dermatological services due to discrimination and financial issues.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Short-term testosterone therapy in women seems safe with few mild side effects, but long-term effects need more research.

Minoxidil, finasteride, and low-level laser light therapy are effective FDA-approved treatments for hair loss.

Dihydrotestosterone makes arteries stiffer in female mice by reducing estrogen receptor expression.

AGA treatments like minoxidil and LLLLT are safe and effective for gender minority patients.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

Testosterone treatment in trans men increases body and facial hair and may lead to hair loss over time, but severe skin issues are rare.

The conclusion is that published guidelines are improving transgender medical care, but more research and education in transgender medicine are needed.

Gender identity can be more diverse than just male or female.

Sex hormones, especially androgens, play a key role in causing acne.

Testosterone replacement is recommended for men with low testosterone levels and symptoms of hypogonadism.

Transgender females can reach their target estrogen levels using estradiol patches, especially if oral treatments fail or if they're at risk for blood clots. Often, the highest dose patch is needed.

The document concludes that non-binary individuals need compassionate support and recognition in healthcare, without being pathologized.

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

Non-binary transgender individuals need personalized hormonal treatments for better well-being and quality of life.

BMI is not a significant predictor of complications after gender-affirming penile inversion vaginoplasty.

High doses of cyproterone acetate increase the risk of brain tumors in women, but the risk decreases after stopping the medication.

The document concludes that personalized hormonal treatments are important for transgender individuals and more research is needed for non-binary treatments.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Men and women react differently to opioids, with hormones potentially influencing these differences.

PCOS increases the risk of heart disease and type 2 diabetes in women.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Hormone therapy in transgender individuals can increase acne and affect hair growth and loss.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Men and women experience skin aging differently due to changes in sex hormone levels with age.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Skin diseases linked to insulin resistance should be managed to prevent diabetes and reduce heart disease risk.