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This study observed that in an ex vivo setting, 17β-estradiol increased CB1 expression in human hair follicles, suggesting possible sensitivity to endocannabinoids and a potential mechanism for hair therapy.

This study found that topical BPM31543 was safe, tolerable, and showed potential to reduce chemotherapy-induced alopecia at higher dosing levels among adult women with cancer receiving taxane-based chemotherapy.

In this study, hair from forearms showed higher cortisol levels than hair from lower legs, suggesting a localized cortisol response in hair.

This study reports that Cyperus rotundus L. (nut grass) shows promise as a natural hair removal agent, with compounds targeting hair follicles and potentially offering an alternative to chemical depilatories, demonstrated by its efficacy in clinical trials and comparable results to some laser treatments.

This study found a strong dose-related increase in the risk of intracranial meningiomas associated with high doses of cyproterone acetate, with some reduction in risk after stopping the treatment.

This study reports that a novel multi-compound Blend, tested on ex vivo human hair follicles, promotes hair growth by enhancing elastin deposition and dermal papilla inductivity more effectively than isopropyl cloprostenate, suggesting benefits through elastogenesis and modulation of Wnt signaling.

This review discusses the pharmacological properties and clinical applications of cyproterone acetate and similar antiandrogens, noting previous failures in local applications due to concentration limitations; it reports no new empirical results.

This study reports the discovery of LX-38, a new high-affinity non-steroidal antagonist that could provide the therapeutic benefits of current BPH and AGA treatments without the hormonal side effects, utilizing a distinct "Orthogonal T-Stacking" scaffold for binding.

In this study, dexpanthenol exhibited antiepileptic and antidepressant-like effects in mice without impacting their motor coordination.

This study used molecular docking simulations to identify Adapalene, Diosmin, and Azelastine as promising drugs for repurposing against onchocerciasis by targeting proteins in the parasite and its endosymbiont; further research is needed to confirm their efficacy.

This study found that patients with alopecia areata and less than 50% hair loss showed a good response to pulse therapy with methylprednisolone, while those with more extensive hair loss also improved but required more courses.

This study found that human hair follicles can function like a peripheral hypothalamic-pituitary-adrenal axis, synthesizing cortisol in response to corticotropin-releasing hormone and adrenocorticotropic hormone stimulation.

This study investigated spanlastic nanovascular drug delivery systems and found that they can effectively enhance the transport and continuous release of medicines with small particle size, low polydispersity index, and satisfactory entrapment efficiency, showing potential as carriers for drug delivery.

This review discusses the challenges in optimizing glucocorticoid treatment for classic 21-hydroxylase deficiency, emphasizing individualized care and the need for comprehensive management, but presents no new findings.

This study developed a validated method using UPLC-MS/MS to analyze 37 hormones in human hair, enabling broader hormonal profiling for identifying endocrine disorders.

This study found that dexamethasone nanocrystals significantly increased drug penetration into skin compared to a traditional cream formulation, suggesting potential benefits for treating inflammatory skin conditions.

This phase II trial found that BI 2536 demonstrated limited antitumor activity across five solid tumor types, with no confirmed objective responses observed.

This study found that a combination of spermidin, rutine, and zeaxantine effectively reduced staurosporin-induced apoptosis in cultured hair follicle dermal papilla cells, potentially preventing the regression phase in the hair follicle cycle.

Using a special solvent can make Cacumen Platycladi essential oil more effective for treating hair loss.

This study used molecular docking to identify stiripentol as a potential new inhibitor of the SRD5A2 enzyme, which is targeted for treating androgen-related diseases; however, in vivo trials are needed to validate its efficacy.

This review discusses the evolution of Cereblon ligands in PROTAC technology, highlighting chemical innovations that may enhance drug-likeness and applicability in protein degradation, while noting challenges and future research directions.

This study found that prevelex coatings on microwell array devices enhanced the formation of uniform cell spheroids and enabled the development of hair follicles in tissue engineering applications.

This study found that certain molecular quantum descriptors can be directly correlated with the biological activity of benzo[c]quinolizin-3-ones, potentially aiding in the identification and design of active compounds.

In this study, researchers developed an LC-MS/MS method to accurately quantify cortisone and cortisol levels in human scalp hair, finding that concentrations decrease predictably along the hair shaft, which could assist in identifying abnormal glucocorticoid exposure.

This study found that a highly resistant structure, located at the interface between the cuticle and cortex of human hair, acts as a penetration barrier, which the authors propose to name the "cuticle anchored resistant base" or CARB.

This study found that ALRN-6924 effectively protected human hair follicles from cyclophosphamide-induced damage in an ex vivo setting, suggesting it may reduce both acute and permanent chemotherapy-induced alopecia.

Cromolyn sodium's effectiveness for treating asthma in children under 2 is unclear, possibly more beneficial for older children, and further research is needed.

This case study describes a 30-year-old woman with ACTH-independent Cushing's syndrome from adrenal carcinoma, who showed significant health improvement and normalized tests 18 months after left adrenalectomy.