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Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

Different types of skin cells play specific roles in development, healing, and cancer.

Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Women with PCOS have a higher risk of diabetes and heart problems, especially when they get older.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

RNAi-based biopesticides could be safe and effective for pest control with careful development and risk assessment.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Early detection and intensive treatment of diseases caused by Staphylococcus aureus toxins are crucial for reducing severe health effects.

Oxidative stress contributes to hair graying and loss as we age.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

The research found that Atypical Progeroid Syndrome has unique symptoms and is not caused by the buildup of a certain mutant protein.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

New treatments targeting specific genes show promise for treating keratin disorders.

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

Olive oil compounds may help prevent cancer in animals, but human results are mixed.

MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.