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    Did you mean Cell cycle inhibitor?
    Glossary Cell cycle inhibitor

    molecule that halts or slows down cell division

    A cell cycle inhibitor, also known as a cell cycle suppressor or cell cycle regulator, is a molecule that can halt or slow down the process of cell division. These inhibitors play a crucial role in controlling cell growth and ensuring that cells do not divide uncontrollably, which is important for preventing conditions like cancer. For example, proteins like p21 and p27 are well-known cell cycle inhibitors that can stop the cell cycle at specific checkpoints, allowing for DNA repair or triggering cell death if the damage is irreparable.

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    Research 30 of 1000+

    1. Maternal androgen excess inhibits fetal cardiomyocytes proliferation through RB-mediated cell cycle arrest and induces cardiac hypertrophy in adulthood Journal of Endocrinological Investigation · 2023 · 2 citations
    2. Embryonic NIPP1 depletion in keratinocytes triggers a cell-cycle arrest and premature senescence in adult mice Journal of Investigative Dermatology · 2024
    3. 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia Journal of Investigative Dermatology · 2023
    4. Immune cell regulation of the hair cycle Experimental Dermatology · 2020 · 27 citations
    5. New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence Journal of Investigative Dermatology · 2012 · 68 citations
    6. Circ-Smad5 retards the G1/S transition of cell cycle via inhibiting the activity of wnt/lef/cyclind1 signaling in JB6 cells Genes & Diseases · 2020 · 10 citations
    7. Editorial: Stem cell exhaustion in aging Frontiers in Aging · 2024 · 13 citations
    8. Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse 2023
    9. Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse 2023
    10. Injury suppresses Ras cell competitive advantage through enhanced wild-type cell proliferation bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 1 citations
    11. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012 · 321 citations
    12. Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors Science · 2001 · 153 citations
    13. Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing β-Catenin Stem cells · 2013 · 3 citations
    14. FGF signaling for hair cycle resting phase alleviates radiation alopecia Journal of Dermatological Science · 2016 · 1 citations
    15. Disrupted citric acid metabolism inhibits hair growth Journal of dermatology · 2022 · 1 citations
    16. N-(3,5-Dimethylphenyl)-3-Methoxybenzamide (A3B5) Targets TRP-2 and Inhibits Melanogenesis and Melanoma Growth 2011 · 15 citations
    17. 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia Journal of Investigative Dermatology · 2022 · 1 citations
    18. Cyclin-dependent kinase inhibitors, p21waf1/cip1 and p27kip1, are expressed site- and hair cycle-dependently in rat hair follicles Journal of Dermatological Science · 2001 · 9 citations
    19. Chemotherapy-Induced Hair Loss: The Use of Biomarkers for Predicting Alopecic Severity and Treatment Efficacy Biomarker Insights · 2019 · 10 citations
    20. HIF‐2α/ARNT complex regulates hair development <i>via</i> induction of p21 <sup>Waf1/Cip1</sup> and p27 <sup>Kip1</sup> The FASEB Journal · 2014 · 4 citations
    21. Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair Developmental Cell · 2013 · 52 citations
    22. Small RNAs Loom Large During Reprogramming Cell stem cell · 2011 · 18 citations
    23. Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne 2009 · 65 citations
    24. 520 The protective effects of Apocynin against ultraviolet B-induced cellular senescence in human keratinocytes Journal of Investigative Dermatology · 2022
    25. Chemotherapy-Induced Alopecia Seminars in Cutaneous Medicine and Surgery · 2009 · 155 citations
    26. Deciphering principles of morphogenesis from temporal and spatial patterns on the integument Developmental Dynamics · 2015 · 19 citations
    27. mTOR signaling in hair follicle and hair diseases: recent progress Frontiers in medicine · 2023
    28. Pharmacological Treatment of Alopecia InTech eBooks · 2018 · 1 citations
    29. Message of nexin 1, a serine protease inhibitor, is accumulated in the follicular papilla during anagen of the hair cycle Journal of Cell Science · 1995 · 37 citations
    30. Ruxolitinib reverses alopecia areata via a triple mechanism: JAK-STAT inhibition, localized oxidative stress attenuation and selective apoptosis modulation Journal of Translational Autoimmunity · 2026