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    Glossary ATP-sensitive potassium channels

    regulate potassium ion flow based on cellular energy levels

    ATP-sensitive potassium channels (KATP channels) are specialized proteins found in the cell membrane that help regulate the flow of potassium ions in and out of the cell. These channels are sensitive to the levels of ATP (adenosine triphosphate), the cell's main energy currency, and they open or close in response to changes in ATP concentration. This mechanism allows the channels to play a crucial role in linking the cell's metabolic state to its electrical activity, which is important in various physiological processes such as insulin release, muscle contraction, and neuronal activity.

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    1. Human hair follicles contain two forms of ATP‐ sensitive potassium channels, only one of which is sensitive to minoxidil The FASEB Journal · 2008 · 102 citations
    2. The ATP sensitive potassium channel (KATP) is a novel target for migraine drug development Frontiers in Molecular Neuroscience · 2023 · 13 citations
    3. The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels Molecular pharmacology · 2022 · 5 citations
    4. 507 Trial to investigate the role of ATP-sensitive potassium channels (KATPc) in dermal papilla cells (DPCs) Journal of Investigative Dermatology · 2024
    5. Investigations into the roles of potassium channels in hair growth : studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches Bradford Scholars (University of Bradford) · 2010
    6. Minoxidil prevents 3,4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK Journal of Neurochemistry · 2008 · 22 citations
    7. Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol–response curve in porcine detrusor muscle Arab Journal of Urology · 2012 · 3 citations
    8. The Role of ATP-Sensitive Inward Rectifier Potassium Channels In The Regulation of Reactive Oxygen Species In The Western Honey Bee, APIS Mellifera L. 2022
    9. Pharmacological evidence for the involvement of adenosine triphosphate sensitive potassium channels in chloroquine-induced itch in mice Pharmacological Reports · 2017 · 9 citations
    10. Immunohistochemical, pharmacovigilance, and omics analyses reveal the involvement of ATP-sensitive K+ channel subunits in cancers: role in drug–disease interactions Frontiers in Pharmacology · 2023 · 3 citations
    11. Novel and established potassium channel openers stimulate hair growth in vitromodes of action in hair follicles.: implications for their 2005
    12. Comparison of the effects of the K+-channel openers cromakalim and minoxidil sulphate on vascular smooth muscle British Journal of Pharmacology · 1991 · 33 citations
    13. KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema Journal of Pharmacology and Experimental Therapeutics · 2020 · 18 citations
    14. The Possible Involvement of KATP Channels in Cholestatic Pruritus in Mice Research Square (Research Square) · 2024
    15. Minoxidil suppressed mitochondrial depolarization and subsequent neuronal cell death by decreasing intracellular potassium level 日本薬理学会年会要旨集 = · 2018
    16. Novel and Established Potassium Channel Openers Stimulate Hair Growth In Vitro: Implications for their Modes of Action in Hair Follicles Journal of Investigative Dermatology · 2005 · 35 citations
    17. Electrophysiological mechanisms of minoxidil sulfate-induced vasodilation of rabbit portal vein. Circulation Research · 1989 · 47 citations
    18. Characterization of minoxidil/hydroxypropyl-β-cyclodextrin inclusion complex in aqueous alginate gel useful for alopecia management: Efficacy evaluation in male rat European Journal of Pharmaceutics and Biopharmaceutics · 2017 · 19 citations
    19. Promotion effect of acankoreoside J, a lupane-triterpene in Acanthopanax koreanum, on hair growth Archives of Pharmacal Research · 2012 · 17 citations
    20. Nitric oxide-dependent vasodilation induced by minoxidil in isolated rat aorta General physiology and biophysics · 2021 · 1 citations
    21. Hair & Cutaneous Development Journal of Investigative Dermatology · 2012
    22. Elastogenesis Stimulation by Minoxidil or Nebivolol Reduces Premature Aging of the Aortic Wall in Diabetic Mice 2024
    23. Should Oral Minoxidil be Our First Choice for Treatment of Alopecia? International Journal of Trichology · 2025
    24. Cantú Syndrome Is Caused by Mutations in ABCC9 The American Journal of Human Genetics · 2012 · 148 citations
    25. Minoxidil opens mitochondrial K<sub>ATP</sub> channels and confers cardioprotection British Journal of Pharmacology · 2004 · 28 citations
    26. K <sub>ATP</sub> Channels and Cardiovascular Disease Circulation Research · 2013 · 144 citations
    27. Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231 BMC Pharmacology and Toxicology · 2013 · 68 citations
    28. 2‐Deoxy‐d‐glucose enhances tonic inhibition through the neurosteroid‐mediated activation of extrasynaptic GABA<sub>A</sub> receptors Epilepsia · 2016 · 44 citations
    29. Hair-growth as anti-aging Drug delivery system · 2009 · 1 citations
    30. Acquired Generalized Hypertrichosis Due to Diazoxide 2013 · 3 citations