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    Glossary Androgen Receptor

    protein in cells that binds male hormones to regulate genes

    The androgen receptor (AR) is a type of protein found inside cells that binds to androgens, which are male hormones like testosterone and dihydrotestosterone. This binding activates the receptor, allowing it to enter the cell nucleus and influence the expression of specific genes, playing a crucial role in the development and maintenance of male characteristics, as well as in conditions like androgenic alopecia (male pattern baldness).

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    1. Estrogen and Progesterone Receptors in Androgenic Alopecia Versus Alopecia Areata American Journal of Dermatopathology · 1998 · 27 citations
    2. Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp Journal of Endocrinology · 1998 · 227 citations
    3. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships Current Medicinal Chemistry · 2000 · 204 citations
    4. The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit Journal of Investigative Dermatology Symposium Proceedings · 2003 · 130 citations
    5. The role of androgen and androgen receptor in skin-related disorders Archives of Dermatological Research · 2012 · 124 citations
    6. Skeletal Site-Dependent Expression of the Androgen Receptor in Human Osteoblastic Cell Populations Calcified Tissue International · 1997 · 123 citations
    7. Androgen receptor–mediated inhibition of cutaneous wound healing 2002 · 108 citations
    8. Androgens and androgen receptor action in skin and hair follicles Molecular and Cellular Endocrinology · 2017 · 100 citations
    9. Polymorphisms of the Androgen Receptor Gene and the Estrogen Receptor β Gene Are Associated with Androgen Levels in Women1 The Journal of Clinical Endocrinology and Metabolism · 2001 · 93 citations
    10. Visualising Androgen Receptor Activity in Male and Female Mice PloS one · 2013 · 89 citations
    11. The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function American Journal of Pathology · 2003 · 72 citations
    12. Androgen receptors and their biology Vitamins and hormones · 2001 · 66 citations
    13. Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer Breast Cancer Research and Treatment · 2016 · 59 citations
    14. Significance of the polyglutamine tract polymorphism in the androgen receptor Urology · 2001 · 54 citations
    15. Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome Fertility and Sterility · 2008 · 44 citations
    16. Androgen receptor gene polymorphisms and risk for androgenetic alopecia: a meta-analysis Clinical and Experimental Dermatology · 2011 · 41 citations
    17. Membrane androgen receptors may mediate androgen reinforcement Psychoneuroendocrinology · 2010 · 37 citations
    18. Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia PLOS ONE · 2014 · 36 citations
    19. Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor 2015 · 31 citations
    20. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013 · 30 citations
    21. CAG Repeat Testing of Androgen Receptor Polymorphism: Is This Necessary for the Best Clinical Management of Hypogonadism? The Journal of Sexual Medicine · 2013 · 29 citations
    22. Cross-species sensitivity to a novel androgen receptor agonist of potential environmental concern, spironolactone Environmental Toxicology and Chemistry · 2013 · 25 citations
    23. Effects of Short-Term Finasteride on Apoptotic Factors and Androgen Receptors in Prostate Cancer Cells The Journal of Urology · 2008 · 25 citations
    24. Testosterone levels in relation to oral contraceptive use and the androgen receptor CAG and GGC length polymorphisms in healthy young women Human Reproduction · 2006 · 25 citations
    25. Androgen receptor modulators: a review of recent patents and reports (2012-2018) Expert Opinion on Therapeutic Patents · 2019 · 23 citations
    26. Evaluation of androgen receptor gene as a candidate gene in female androgenetic alopecia International Journal of Dermatology · 2009 · 23 citations
    27. Androgen receptor: A promising therapeutic target in breast cancer Critical Reviews in Clinical Laboratory Sciences · 2019 · 21 citations
    28. Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors Steroids · 2010 · 19 citations
    29. Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2018 · 18 citations
    30. Recent discoveries and developments of androgen receptor based therapy for prostate cancer MedChemComm · 2015 · 17 citations