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    Glossary Androgen Receptor Signaling

    hormones like testosterone bind to receptors, influencing gene expression

    Androgen Receptor Signaling, also known as AR signaling, is a biological pathway where androgens (male hormones like testosterone) bind to androgen receptors in cells. This binding activates the receptors, which then influence the expression of specific genes, affecting various bodily functions such as hair growth, muscle development, and reproductive processes. In the context of hair, AR signaling can play a role in conditions like androgenetic alopecia (pattern hair loss).

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    1. Androgen Receptor–Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia Journal of Investigative Dermatology · 2022 · 6 citations
    2. Hair Thickness Growth Effect of Adenosine Complex in Male-/Female-Patterned Hair Loss via Inhibition of Androgen Receptor Signaling International journal of molecular sciences · 2024
    3. Androgen receptor signaling as a new target for intervention in acute myeloid leukemia Blood Advances · 2025
    4. The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells Journal of Investigative Dermatology · 2015 · 46 citations
    5. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell · 2020 · 139 citations
    6. Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling PloS one · 2014 · 56 citations
    7. Visualising Androgen Receptor Activity in Male and Female Mice PloS one · 2013 · 89 citations
    8. Regulation of masculinization: androgen signalling for external genitalia development Nature Reviews Urology · 2018 · 45 citations
    9. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013 · 30 citations
    10. Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain Frontiers in Endocrinology · 2024 · 3 citations
    11. Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 2 citations
    12. Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo International Journal of Molecular Sciences · 2026
    13. Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2018 · 18 citations
    14. COVID-19 Severity and Androgen Receptor Polymorphism Biology · 2022 · 7 citations
    15. Androgen Signaling in Sertoli Cells theses.fr (ABES) · 2014
    16. ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer 2013 · 224 citations
    17. Estrogen and androgen signaling in the pathogenesis of BPH Nature reviews. Urology · 2011 · 149 citations
    18. Androgens and androgen receptor action in skin and hair follicles Molecular and Cellular Endocrinology · 2017 · 100 citations
    19. Androgen modulation of Wnt/β-catenin signaling in androgenetic alopecia Archives of Dermatological Research · 2018 · 39 citations
    20. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells Biological and Pharmaceutical Bulletin · 2018 · 23 citations
    21. Transcriptome analysis to identify the downstream genes of androgen receptor in dermal papilla cells BMC Genomic Data · 2022 · 1 citations
    22. Discovery of (2<i>S</i>)-<i>N</i>-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment Journal of Medicinal Chemistry · 2023
    23. Therapeutic Potentiality of Celtis choseniana Nakai on Androgenic Alopecia through Repression of Androgen Action and Modulation of Wnt/β-catenin Signaling Natural product sciences · 2023
    24. Selective androgen receptor modulators: a critical appraisal Frontiers in Endocrinology · 2025 · 2 citations
    25. Stauntonia hexaphylla Extract Ameliorates Androgenic Alopecia by Inhibiting Androgen Signaling in Testosterone-induced Alopecia Mice Iranian Journal of Pharmaceutical Research · 2023
    26. Anti-androgen hormonal therapy for cancer and other diseases European Journal of Pharmacology · 2019 · 65 citations
    27. Targets to treat androgen excess in polycystic ovary syndrome Expert Opinion on Therapeutic Targets · 2015 · 14 citations
    28. A randomized phase II trial on the addition of dutasteride to combined androgen blockade therapy versus combined androgen blockade therapy alone in patients with advanced or metastatic salivary duct carcinoma – the DUCT study protocol BMC Cancer · 2024 · 4 citations
    29. Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways InTech eBooks · 2017 · 1 citations
    30. Androgen excess: a hallmark of polycystic ovary syndrome Frontiers in endocrinology · 2023