13 citations
,
May 2012 in “Cutaneous and ocular toxicology” In this study, researchers found no significant differences in vitamin B12, folate, and homocysteine metabolism between patients with alopecia areata and controls, suggesting no association with vitamin B12 deficiency.
2 citations
,
December 2015 in “Journal of dermatology research and therapy” This study compared serum zinc, vitamin B12, folic acid levels, iron metabolism, and thyroid function between chronic telogen effluvium patients and healthy controls, but it reports no specific clinical results.
1 citations
,
September 2007 in “Neuromuscular disorders” This study suggests that long-term treatment with valproate, acetylcarnitine, folic acid, and vitamin B12 may benefit children with SMA types II and III by improving muscle strength and function without significant adverse effects.
1 citations
,
November 1988 in “Veterinary Record” In this case study, oral folic acid therapy resulted in noticeable improvement and eventual recovery from hair loss and skin issues in a three-week-old Charolais calf.
July 2025 in “ALEXMED ePosters” In this study, the researchers aimed to evaluate the levels of substance P, folic acid, and ferritin in the serum of female patients experiencing hair fall and trichodynia.
March 2022 in “IP Indian journal of clinical and experimental dermatology” This study found that ferritin and cobalamin levels were better indicators than hemoglobin in assessing chronic nonscarring hair loss in females of reproductive age.
October 2021 in “Utah State Research and Scholarship (Utah State University)” This study found that folic acid deficiency in infant mice moderately worsened rotaviral disease, while zinc deficiency did not significantly affect rotaviral disease progression.
January 2019 in “Türkiye klinikleri dermatoloji dergisi” This study investigated the role of serum iron, ferritin, zinc, and folic acid levels in women with diffuse hair loss but reports no findings.
September 2018 in “PubMed” This review discusses various strategies, including vitamin A and dextromethorphan supplementation, to manage methotrexate toxicity and improve adherence in patients with rheumatic diseases, but reports no new clinical results.
January 2018 in “Hair therapy & transplantation” This study aimed to identify possible associations between a hair pull test and various pathological, biochemical, and hematological parameters in Czech patients with different types of alopecia.
3 citations
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February 2023 in “Journal of drug delivery science and technology” In vitro, this study found that PTX and HU SF-FA NLCs showed greater cytotoxicity and apoptosis in ovarian cancer cells than pure paclitaxel, suggesting promise as a targeted drug delivery platform.
October 2007 in “European Neuropsychopharmacology” 
155 citations
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August 1991 in “Journal of The American Academy of Dermatology” This article reviews methotrexate's pharmacokinetics and toxicity, emphasizing the role of urinary excretion and leucovorin in avoiding most toxic reactions; it provides no new clinical results.
134 citations
,
December 2018 in “Dermatology and Therapy” This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.
75 citations
,
November 2009 in “Gynecological Endocrinology” This study found that both myo-inositol and metformin helped restore normal menstrual cycles in patients with PCOS, but myo-inositol appeared to be more effective in inducing pregnancy.
63 citations
,
May 2017 in “American Journal of Clinical Dermatology” This review found that patients with alopecia areata may have lower levels of vitamin D, zinc, and folate, but conflicting evidence precludes definitive clinical recommendations for micronutrient supplementation.
54 citations
,
April 2007 in “Gastroentérologie clinique et biologique” This review highlights that bariatric surgery can increase nutritional deficiencies in morbidly obese patients, with particular emphasis on the risks of deficiency due to reduced food intake and malabsorption.
43 citations
,
October 1955 in “The journal of nutrition/The Journal of nutrition” This study found that male germ-free rats fed semisynthetic diets do not grow as rapidly as their conventional counterparts and require dietary biotin for normal metabolism and folic acid biosynthesis.
25 citations
,
January 2017 in “International Journal of Trichology” This study found that nutritional deficiencies, particularly in amino acids and certain micronutrients, are common in individuals with hair loss across all types of alopecia.
20 citations
,
November 1943 in “Experimental Biology and Medicine” This study found that inositol supplementation in rats improved growth and prevented hair loss, and combining it with folic acid and B6 resulted in even better growth rates.
19 citations
,
March 2021 in “Obesity surgery” This study found that hair loss is common following metabolic and bariatric surgery, particularly among younger women with low serum levels of zinc, folic acid, and ferritin.
19 citations
,
January 2019 in “International Journal of Trichology” This consensus paper reviews expert opinions on treating telogen effluvium but reports no new clinical findings.
19 citations
,
October 1971 in “The BMJ” Anticonvulsant drugs may cause temporary chromosomal abnormalities.
10 citations
,
January 2015 in “Journal of Dermatology and Dermatologic Surgery” In this study, telogen effluvium was commonly found to be associated with iron-deficiency anemia and hypothyroidism among female patients in Makkah, Saudi Arabia.
10 citations
,
January 2010 in “PubMed” This article reviews current hair loss treatments, proposing a hypothesis that a combination of drugs, supplements, and therapies may effectively manage hair loss, but presents no new clinical results.
8 citations
,
September 2021 in “Journal of Cosmetic Dermatology” This review discusses the varied levels of evidence linking nutritional supplements and antioxidants to dermatological disorders, but it reports no new clinical results and highlights the need for rigorous trials.
7 citations
,
July 2020 in “Dermatologic therapy” This review discusses premature graying of hair, highlighting risk factors like smoking and vitamin deficiencies, and suggests that addressing underlying conditions may reverse the graying process.
5 citations
,
June 2020 in “Experimental dermatology” This study found that redheaded individuals had higher levels of vitamin D precursor 25(OH)D3 compared to non-redheaded individuals, suggesting a physiological adaptation to low UVB radiation in Europe.
4 citations
,
March 2006 in “Journal of renal nutrition” This study found that hemodialysis patients taking water-soluble vitamins had a 16% lower mortality risk compared to those not taking any, but the specific supplementation needed remains unclear.
3 citations
,
March 2020 in “Dermatology Research and Practice” In this study, 33 overweight women with normal hormone levels but showing PCOS symptoms experienced substantial reductions in acne lesions and improvements in hirsutism and menstrual irregularities after 8 weeks of Tracnil™ treatment, with minimal adverse reactions reported.