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    Glossary 5-Fluorouracil

    chemotherapy drug that inhibits cancer cell DNA synthesis

    5-Fluorouracil (5-FU) is a chemotherapy medication used to treat various types of cancer, including colon, breast, and skin cancers. It works by interfering with the DNA and RNA synthesis of cancer cells, preventing them from growing and dividing.

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    1. Docetaxel, cisplatin and 5-fluorouracil in patients with locally advanced unresectable head and neck cancer: a phase I–II feasibility study Annals of Oncology · 2004 · 78 citations
    2. The efficacy of adding topical 5‐fluorouracil to micro‐needling in the treatment of vitiligo: A randomized controlled trial Journal of Cosmetic Dermatology · 2023 · 16 citations
    3. Corticosteroid Atrophy Plaque on the Scalp Treated with 5-Fluourouracil and Bleomycin Infusion in the MMP Technique Skin Appendage Disorders · 2024 · 1 citations
    4. Phenytoin or Spironolactone Intervention Counteracts 5-Fluorouracil–Induced Alopecia in Rats by Suppressing Oxidative Stress and Inflammation While Promoting Collagen Synthesis Preprints.org · 2025
    5. Comparison of intralesional triamcinolone acetonide alone and with 5 -fluorouracil for the treatment of keloids Journal of the Pakistan Medical Association · 2025
    6. 5-Fluorouracil induces hair loss by inhibiting β-catenin signaling and angiogenesis Chemico-Biological Interactions · 2025
    7. Treatment of Alopecia Areata using Transdermal Delivery of 5-Fluorouracil by Fractional CO2 Laser versus Intralesional Injection of 5-Fluorouracil Zagazig University Medical Journal · 2024
    8. Fractional CO2 laser versus Microneedling followed by Topical 5 Fluorouracil in the treatment of Non-Segmental Vitiligo 2024
    9. Fractional CO2 laser versus Microneedling followed by Topical 5 Fluorouracil in the treatment of Non-Segmental Vitiligo 2024
    10. Focal Neurotoxicity Associated With Topical 5-Fluorouracil Curēus · 2024
    11. Transient chemotherapy-induced alopecia after intralesional 5-fluorouracil treatment of keloids JAAD Case Reports · 2019 · 3 citations
    12. Comparison of the therapeutic effects of the dietary and topical forms of Zizyphus jujuba extract on oral mucositis induced by 5-fluorouracil: A golden hamster model Journal of Clinical and Experimental Dentistry · 2015 · 37 citations
    13. An injectable photo-crosslinking silk hydrogel system with biphasic release of BTXA and 5-Fu promotes scarless wound healing RSC Advances · 2026
    14. Male Pattern Alopecia Regrowth Following Topical Fluorouracil Therapy JAMA · 1977 · 1 citations
    15. Male pattern alopecia regrowth following topical fluorouracil therapy JAMA · 1977
    16. Microemulsions as a Surrogate Carrier for Dermal Drug Delivery Drug Development and Industrial Pharmacy · 2008 · 117 citations
    17. Cutaneous Reactions to Chemotherapeutic Agents ˜The œAmerican journal of the medical sciences · 2001 · 53 citations
    18. Scalp cooling has no place in the prevention of alopecia in adjuvant chemotherapy for breast cancer European Journal of Cancer · 1994 · 39 citations
    19. Topical delivery of nanoemulsions for skin cancer treatment Applied Materials Today · 2023 · 34 citations
    20. Testing Chemotherapeutic Agents in the Feather Follicle Identifies a Selective Blockade of Cell Proliferation and a Key Role for Sonic Hedgehog Signaling in Chemotherapy-Induced Tissue Damage Journal of Investigative Dermatology · 2014 · 30 citations
    21. Intralesional therapy for the treatment of keratoacanthoma Dermatologic therapy · 2019 · 25 citations
    22. Is skin microneedling a good alternative method of various skin defects removal Dermatologic Therapy · 2018 · 23 citations
    23. NON-PSORALEN TREATMENT OF VITILIGO. PART II. LESS COMMONLY USED AND EXPERIMENTAL THERAPIES International Journal of Dermatology · 1992 · 19 citations
    24. Skin precancer. PubMed · 1998 · 16 citations
    25. A novel approach for follicular delivery of minoxidil for treatment of alopecia Journal of Drug Delivery Science and Technology · 2017 · 9 citations
    26. Extensive donor site keloids in follicular unit extraction hair transplantation International Journal of Trichology · 2017 · 7 citations
    27. Prolonged remissions of metastatic breast cancer achieved with a six-drug regimen of relatively low toxicity Cancer · 1983 · 6 citations
    28. Effect of FOLFOX6 chemotherapy on serum VEGF expression in advanced colorectal cancer patients Revista da Associação Médica Brasileira · 2019 · 4 citations
    29. Hot Stuff: Thermal Imaging Aids in Cellulitis Diagnosis Journal of Investigative Dermatology · 2018 · 4 citations
    30. Hypertrichosis lanuginosa acquisita following cytotoxic chemotherapy Clinical Oncology · 1992 · 4 citations