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    Did you mean Dihydrotestosterone?
    Glossary Dihydrotestosterone

    potent androgen hormone derived from testosterone

    Dihydrotestosterone (DHT) is a potent androgen hormone derived from testosterone through the action of the enzyme 5-alpha-reductase. It plays a crucial role in the development of male characteristics and is also implicated in conditions like androgenic alopecia (male pattern baldness) and benign prostatic hyperplasia.

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    1. Preponderance of serum and intra-hepatic 5α-dihydrotestosterone in males with hepatocellular carcinoma despite low circulating androgen levels Journal of hepatology · 1986 · 8 citations
    2. An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 5-alpha-dihydrotestosterone in human serum and plasma Clinical Chemistry and Laboratory Medicine (CCLM) · 2026
    3. 5 Dihydrotestosterone metabolism Clinics in endocrinology and metabolism · 1986 · 22 citations
    4. DIHYDROTESTOSTERONE AND THE PROSTATE: THE SCIENTIFIC RATIONALE FOR 5α-REDUCTASE INHIBITORS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA 2004 · 235 citations
    5. The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness. The Journal of Clinical Endocrinology and Metabolism · 1994 · 59 citations
    6. Comparative Efficacy of Oral and Topical 5-Alpha Reductase Inhibitors in Reducing Dihydrotestosterone levels across Men with Androgenetic Alopecia: A Network Meta-Analysis incorporating Post-Hoc Analyses of Randomized Clinical Trial Data Open Science Framework · 2026
    7. Dual Wavelength LEDs Induce Reactive Oxygen Species and Nitric Oxide That Inhibit the Production of Dihydrotestosterone by 5‐α Reductase Journal of Biophotonics · 2024
    8. Dihydrotestosterone and 5α-Reductase Humana Press eBooks · 2003
    9. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006 · 58 citations
    10. Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1 Journal of Cellular Biochemistry · 2005 · 27 citations
    11. Dihydrotestosteron und die Rolle der 5α-Reduktasehemmer bei der benignen Prostatahyperplasie Der Urologe · 2002 · 24 citations
    12. Analysis of the microRNA expression profile of normal human dermal papilla cells treated with 5α-dihydrotestosterone Molecular Medicine Reports · 2012 · 22 citations
    13. Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone. Biochemical Pharmacology · 2001 · 22 citations
    14. Role of 5α-dihydrotestosterone in testicular development of gilthead seabream following finasteride administration The Journal of Steroid Biochemistry and Molecular Biology · 2017 · 8 citations
    15. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor 2004 · 408 citations
    16. Safety aspects of androgen treatment with 5α-dihydrotestosterone Andrologia · 2007 · 16 citations
    17. Is the metabolism of testosterone to 5α-dihydrotestosterone required for androgen action in the skin? British Journal of Dermatology · 1982 · 14 citations
    18. Greater conversion of testosterone to 5α-dihydrotestosterone, reflecting increased peripheral 5α-reductase activity in nude mice treated with high doses of cyclosporine A Journal of Steroid Biochemistry · 1990 · 10 citations
    19. Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men. The Journal of Clinical Endocrinology and Metabolism · 1996 · 6 citations
    20. The circulating dihydrotestosterone/testosterone ratio is increased by gut microbial 5α-reductase activity in females EBioMedicine · 2025 · 1 citations
    21. Dihydrotestosterone and the Concept of 5α–Reductase Inhibition in Human Benign Prostatic Hyperplasia European Urology · 2000 · 184 citations
    22. MK-386, an Inhibitor of 5α-Reductase Type 1, Reduces Dihydrotestosterone Concentrations in Serum and Sebum without Affecting Dihydrotestosterone Concentrations in Semen<sup>1</sup> The Journal of Clinical Endocrinology & Metabolism · 1997 · 37 citations
    23. Testosterone Reduces Knee Passive Range of Motion and Expression of Relaxin Receptor Isoforms via 5α-Dihydrotestosterone and Androgen Receptor Binding International Journal of Molecular Sciences · 2014 · 23 citations
    24. Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells Annals of Dermatology · 2016 · 16 citations
    25. Invalidation of a commercially available human 5α-dihydrotestosterone immunoassay Steroids · 2013 · 13 citations
    26. Longitudinal clinical course in patients with 5α-reductase type 2 deficiency treated with testosterone and dihydrotestosterone during infancy and puberty Endocrine journal · 2022
    27. A model for the turnover of dihydrotestosterone in the presence of the irreversible 5α-reductase inhibitors GI198745 and finasteride Clinical Pharmacology & Therapeutics · 1998 · 60 citations
    28. Effects of pre- and post-pubertal dihydrotestosterone treatment on penile length in 5α-reductase type 2 deficiency Endocrine journal · 2019 · 13 citations
    29. Terminalia chebula retz. Fruit Extract Promotes Murine Hair Growth by Suppressing 5α-Reductase and Accelerating the Degradation of Dihydrotestosterone Biomedicines · 2025
    30. The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness The Journal of Clinical Endocrinology and Metabolism · 1994 · 61 citations