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Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

PCOS affects a similar percentage of Black and White women in the Southeastern United States.

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

PCOS affects about 4% of women in the southeastern U.S. equally across Black and White populations.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Human skin can make serotonin and melatonin, which help protect and maintain it.

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

Hair regeneration needs dynamic cell behavior and mesenchyme presence for stem cell activation.

Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Spironolactone treatment increases the amount of testosterone available in the body.

Human skin can make serotonin and melatonin.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.

The Multi-Organ-Chip improves the growth and quality of skin and hair in the lab, potentially replacing animal testing.

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.