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Glossary11α-Hydroxyprogesterone

steroid hormone derived from progesterone with a hydroxyl group

11α-Hydroxyprogesterone is a steroid hormone that is a derivative of progesterone, featuring a hydroxyl group at the 11-alpha position. It plays a role in the biosynthesis of other important steroids, including cortisol and corticosterone, which are crucial for stress response and immune function.

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11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

research 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

7 citations , July 2019 in “The Journal of Steroid Biochemistry and Molecular Biology”

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

research The effect of the antiandrogen IIα-hydroxyprogesterone on sebum production and cholesterol concentration of sebum

27 citations , July 1982 in “British Journal of Dermatology”

The antiandrogen 11α-hydroxyprogesterone effectively reduces skin oil and cholesterol when applied to the skin.

research Synthesis of 11α-hydroxyprogesterone hartens

7 citations , June 1989 in “Steroids”

Researchers successfully made new compounds for hormone level tests, but one attempt led to an unexpected product, correcting a past error.

research Detection of urine metabolites in polycystic ovary syndrome by UPLC triple-TOF-MS

23 citations , August 2015 in “Clinica Chimica Acta”

Researchers found potential urine markers for polycystic ovary syndrome, including testosterone-glucuronide and 11α-hydroxyprogesterone, which may help diagnose the condition.

research ENZYMES

1 citations , November 2011 in “British journal of pharmacology”

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

research Applications of steroid drugs entrapped in cyclodextrins

23 citations , March 2019 in “Environmental Chemistry Letters”

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

research Ovine placental steroid synthesis and metabolism in late gestation†

9 citations , April 2018 in “Biology of reproduction”

Diet changes hormone levels in pregnant ewes by affecting metabolism, not placental synthesis.

The First Syntheses of 16<b>β</b>-Chloro- and 16<b>β</b>-Bromo-cyproterone Acetate

research The First Syntheses of 16β-Chloro- and 16β-Bromo-cyproterone Acetate

3 citations , January 2003 in “Synthetic Communications”

Scientists made two new chemicals that might help treat diseases caused by male hormones.

research Androgen binding profiles of two distinct nuclear androgen receptors in Atlantic croaker (Micropogonias undulatus)

58 citations , June 2000 in “The Journal of Steroid Biochemistry and Molecular Biology”

Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.

Biotransformation of Finasteride by Ocimum sanctum L., and tyrosinase inhibitory activity of transformed metabolites: Experimental and computational insights

research Biotransformation of Finasteride by Ocimum sanctum L., and tyrosinase inhibitory activity of transformed metabolites: Experimental and computational insights

3 citations , December 2014 in “Steroids”

Fermentation of Finasteride with Ocimum sanctum L. creates new metabolite that inhibits tyrosinase.

research Herbal Treatment for Dermatologic Disorders

9 citations , March 2011 in “Oxidative stress and disease”

Some herbal treatments are effective for skin disorders, but more research and regulation are needed.

research MICROBIAL OXIDATION OF FINASTERIDE WITH MACROPHOMINA PHASEOLINA(KUCC 730)

3 citations , November 2017 in “International Journal of Pharmacy and Pharmaceutical Sciences”

α<sub>1</sub>-AR agonist induced piloerection protects against the development of traction alopecia

research α₁-AR agonist induced piloerection protects against the development of traction alopecia

5 citations , December 2015 in “Dermatologic Therapy”

Using a certain drug on the skin can help prevent hair loss caused by pulling on the hair.

$Limits of Visual Detection for Finasteride Polymorphs in Prepared Binary Mixtures: Analysis by X‐ray Powder Diffraction$

research Limits of Visual Detection for Finasteride Polymorphs in Prepared Binary Mixtures: Analysis by X‐ray Powder Diffraction

5 citations , November 2014 in “Journal of Pharmaceutical Sciences”

research Androgens/Androgen Receptor in the Management of Skin Diseases

1 citations , January 2022 in “Journal of Biosciences and Medicines”

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

research Peripubertal Testosterone, 17β-Estradiol and Progesterone Concentrations in Hair and Nails in Dobermann Dogs

July 2023 in “Animals”

Hair and nails can show hormone changes during puberty in dogs.