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5 / 9 resultslearn SCUBE3
a signaling molecule from dermal papilla cells being actively researched
learn Valproic acid
an anticonvulsant repurposed for hair loss via histone inhibition
learn Exosomes
Microscopic delivery system that sends growth-promoting signals to hair follicles
learn Microneedling
technique to create small wounds in skin to activate collagen production and hair growth
Research
5 / 1000+ results![Single‐cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts](/images/research/51160122-1b4f-4da7-a11f-673a77807b34/small/12671.jpg)
research Single‐cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts
Different types of skin cells are organized in a special way in large wounds to help with healing and hair growth.
![942 Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing](/images/research/11a4701e-a075-4efe-ac7a-4f6aea7ada20/small/11462.jpg)
research 942 Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing
Activating the Sonic hedgehog pathway can help regenerate hair follicles during wound healing in mice, potentially improving regeneration after injury.
![Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing](/images/research/9ba0331b-b569-446b-a7e8-4e8e9c553eb2/small/12191.jpg)
research Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing
The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.
![Reawakening GDNF's regenerative past in mice and humans](/images/research/aa71a002-9665-4e80-8749-f2660e59afba/small/12636.jpg)
research Reawakening GDNF's regenerative past in mice and humans
Activating the GDNF-GFRα1-RET signaling pathway could potentially promote skin and limb regeneration in humans and could be used to treat hair loss and promote wound healing.
![Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice](/images/research/92507196-c68e-445e-9657-3c8ef62f7c9f/small/19114.jpg)
research Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice
The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.
Community Join
5 / 189 resultscommunity HairClone: Good info from their site
HairClone aims to rejuvenate miniaturizing hair follicles through follicle banking and cell expansion, with treatments potentially available in the UK by 2022. The process involves extracting, storing, and cloning hair follicles, but full regenerative treatments will take many years to develop.
community Verteporfin and Microneedling
Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.
community New and Interesting HairLoss Studies/Papers/Reviews
Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
community Update: 16 months deep - big 3
The user has seen positive results after 16 months of using topical Finasteride/Minoxidil, microneedling weekly, and Tretinoin for hair loss. There are no reported side effects, and the user advises that the effectiveness of microneedling depends on the pressure applied.
community Hair cloning and injection of dermal papilla cells coming as soon as 2023
Hair cloning and injection of dermal papilla cells are discussed, with skepticism about their availability by 2023. Users mention Minoxidil, finasteride, and hair transplants as current treatments.