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Rubedo Life Sciences is developing a GPX4 modulator, RLS-1496, for hair loss treatment, showing promising hair follicle growth in early tests. Concerns include potential side effects like organ damage, with a realistic market release several years away.

Finasteride can cause side effects like erectile dysfunction and decreased libido, possibly due to increased estradiol from testosterone aromatization, especially in those with higher body fat. Side effects vary widely and may also be influenced by genetic factors or neurosteroid inhibition.

The "DHT itch" is real and likely due to inflammation at the hair follicle, exacerbated by increased testosterone or androgens. Treatments mentioned include dutasteride, minoxidil, finasteride, and various topical solutions.

Taking dutasteride daily at higher doses results in more effective DHT suppression compared to every other day dosing, due to its dose-dependent nature and long half-life. Even at lower doses, dutasteride is more effective than finasteride for hair loss.

The user has been using 1.25mg Finasteride, 5mg Oral Minoxidil, Ketoconazole shampoo, and dermastamping for 1.5 months, noticing thicker hair and less scalp visibility, though changes are more noticeable in photos than in real life. They experienced no side effects from Finasteride but had initial chest discomfort with Oral Minoxidil, which resolved, and they plan to continue updating on their progress.