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Did you mean Prostaglandin D2 Synthase?

Glossary Prostaglandin D2 Synthase

enzyme converting prostaglandin H2 to prostaglandin D2, linked to hair loss

Prostaglandin D2 Synthase (PTGDS) is an enzyme that converts prostaglandin H2 into prostaglandin D2 (PGD2), a lipid compound involved in various physiological processes, including inflammation and allergic responses. In the context of hair biology, elevated levels of PGD2 have been linked to hair loss, particularly in conditions like androgenetic alopecia.

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Research

5 / 1000+ results

research A prostaglandind-synthase-positive mast cell gradient characterizes scalp patterning

6 citations , December 2013 in “Journal of Cutaneous Pathology”

This study found that the distribution of mast cell prostaglandin d-synthase in the scalp spatially aligns with the pattern of androgenetic alopecia, suggesting a programmed vulnerability to hair loss.

research The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A

20 citations , August 2020 in “Scientific Reports”

In this study, low-dose BPA was associated with induced prostatic hyperplasia in rats, potentially mediated by COX-2 and L-PGDS through pathways involving cell proliferation and apoptosis.

research In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss

30 citations , October 2015 in “Journal of Ethnopharmacology”

This study identified several compounds from traditional Chinese medicines that may inhibit prostaglandin D2 synthase, potentially providing promising candidates for treating androgenic alopecia with minimal adverse skin reactions.

Oral Administration of Low-Dose Bisphenol A Promotes Proliferation of Ventral Prostate and Upregulates Prostaglandin D2 Synthase Expression in Adult Rats

research Oral administration of low-dose bisphenol A promotes proliferation of ventral prostate and upregulates prostaglandin D₂ synthase expression in adult rats

14 citations , June 2015 in “Toxicology and Industrial Health”

This study found that low doses of bisphenol A may increase proliferation of the ventral prostate in adult rats by altering the estrogen to androgen ratio and gene expression.

Prostaglandin D2, Prostaglandin D2 Receptor, Prostaglandin D2 Synthase

research Prostaglandin D2(PGD2); prostaglandin D2 receptor (CRTH2; GPR44; CD294); prostaglandin D2 synthase (PTGDS)

2 citations , April 2012 in “Science-business Exchange”

Blocking a protein called prostaglandin D2 might help treat hair loss.

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Community Join

5 / 68 results

community Doubts about castor oil

5 upvotes 7 years ago

Castor oil's effectiveness for hair growth is debated, with concerns about its impact on skin health and prostaglandin levels. Some users suggest combining it with coconut oil and using it alongside finasteride for better results, while others recommend sticking to proven synthetic treatments.

community Painkillers May Block Minoxidil

12 upvotes 1 year ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

6 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community You will lose hair if your prostaglandins aren't in balance

56 upvotes 1 year ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

community Has anyone here tried topical synthetic prostaglandins (Bimatoprost, Latanoprost, cetirizine) to stimulate hair growth?

6 upvotes 2 years ago

The conversation discusses using topical synthetic prostaglandins like Bimatoprost, Latanoprost, and cetirizine for hair growth. The user shares a link suggesting these treatments may be effective.

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Learn

3 / 801 results

learn Cetirizine

popular antihistamine showing promise for hair loss as an anti-inflammatory and prostaglandin inhibitor

How does cetirizine reduce inflammation linked to hair loss? Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.

learn Setipiprant

What is Setipiprant and how does it differ from DHT blockers like finasteride or dutasteride? Setipiprant blocks the prostaglandin D2 receptor DP2 rather than the DHT pathway that finasteride and dutasteride act on. The one published human trial — a 169-man, 24-week phase 2a study at 2,000 mg a day — reported no statistically significant improvement in hair density over placebo, and setipiprant is not an approved hair-loss medicine anywhere.
How does Setipiprant work on the scalp to potentially promote hair regrowth? Setipiprant blocks the DP2 (CRTH2) receptor that prostaglandin D₂ acts through, and PGD₂ is reported to be elevated in balding scalp — but the one published placebo-controlled trial in men (DuBois 2021, n=169) found no significant hair regrowth. It is an experimental compound, not an approved hair-loss medicine.

learn Latanoprost

How does latanoprost work to make eyelashes and possibly scalp hair grow? Studies report that latanoprost, a prostaglandin analog, lengthens the anagen (growth) phase of hair follicles, which is the mechanism given for the eyelash thickening seen in glaucoma patients; on the scalp the evidence is one 16-man pilot study and animal work, so the effect there is unproven.

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