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research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia

1707 citations , December 2003 in “The New England Journal of Medicine”

Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.

The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia

research The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment among Men with Benign Prostatic Hyperplasia

1054 citations , February 1998 in “The New England Journal of Medicine”

In this study, men with benign prostatic hyperplasia who took finasteride for four years experienced reduced urinary symptoms, fewer surgeries, less acute urinary retention, increased urinary flow rates, and decreased prostate volume.

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

1040 citations , October 1992 in “The New England Journal of Medicine”

In this study, 5 mg of finasteride per day significantly improved urinary symptoms and reduced prostate volume in men with benign prostatic hyperplasia, but increased the risk of sexual dysfunction.

research Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing

527 citations , December 2011 in “Proceedings of the National Academy of Sciences”

This study found that dextran-based hydrogels promoted significant neovascularization and skin regeneration in mouse models of third-degree burns, without the need for additional growth factors or cells.

research A Ca ²⁺ /calmodulin-dependent protein kinase required for symbiotic nodule development: Gene identification by transcript-based cloning

477 citations , March 2004 in “Proceedings of the National Academy of Sciences”

This study reports that the DMI3 gene, essential for nodule formation in legume-rhizobial symbiosis, encodes a calcium/calmodulin-dependent protein kinase, highlighting its role in multiple plant symbioses.

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Community Join

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community Pro as Heck Guide to Hairloss

48 upvotes 6 years ago

The conversation discusses a hair loss treatment protocol involving minoxidil, finasteride, ketoconazole shampoo, and RU58841. The user reports success with this regimen, particularly noting RU58841's effectiveness in regrowing hair without side effects.

community Progress in 10 months for 25 yo (my plan)

130 upvotes 3 months ago

A 25-year-old shared their 10-month hair loss treatment progress using dutasteride, minoxidil, microneedling, red light therapy, Nizoral shampoo, and a hair oil. They experienced mild side effects with finasteride but none with dutasteride, and noticed significant improvement with the new regimen.

community Promising new data on peptide serums (not sponsored)

7 upvotes 7 months ago

Combining Minoxidil with peptide serums like Redensyl, Procapil, and Capixyl is more effective for hair growth than using Minoxidil alone, increasing hair density and thickness. However, some users are skeptical about the effectiveness of peptides, suggesting other ingredients or factors might contribute to the results.

community Prolonged shedding over last 15 months

2 upvotes 7 months ago

The user has been experiencing prolonged hair shedding despite using Dutasteride, Minoxidil, and topical Finasteride, with blood tests showing high free testosterone and low SHBG. Suggestions include adjusting Minoxidil dosage, considering topical anti-androgens like RU58841, and addressing metabolic factors to increase SHBG.

community Ray Peat: Testosterone Isn’t the Culprit, Prolactin and Cortisol Drive Hair Loss (2016)

in Research/Science 110 upvotes 10 months ago

Prolactin and cortisol are identified as key factors in hair loss, with stress hormones impacting hair shedding. Finasteride and minoxidil are effective treatments, while DHT's role and individual sensitivity are significant factors.

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Learn

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Seeing too much hair on your brush lately? Procapil might help your strands hang on longer. Procapil may strengthen hair and reduce hair loss by improving follicle health.
Can a liquid formula with Procapil do more than your usual multivitamin? Procapil is a cosmetic ingredient, not an approved hair-loss drug: the published studies on it are small and test it in combination with caffeine or platelet-rich plasma, so none isolates its own effect, and the percentages quoted in marketing come from the ingredient supplier's unpublished studies. Vitamins are reported to help hair only where there is a deficiency, so the two are aimed at different problems rather than ranked against each other.
Tried everything and still getting bald patches? Procapil may help calm the immune response Procapil is a cosmetic ingredient complex; laboratory studies of its individual ingredients report anti-inflammatory effects, but no published clinical trial has tested it in alopecia areata or any other immune-related hair loss. Spreading bald patches should be assessed by a dermatologist.
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