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    Glossary PPAR Agonists

    activate nuclear receptors to regulate metabolism and inflammation

    PPAR Agonists, or Peroxisome Proliferator-Activated Receptor Agonists, are compounds that activate PPARs, which are nuclear receptor proteins that regulate gene expression. These receptors play a crucial role in metabolism, inflammation, and cell differentiation, making PPAR agonists valuable in treating conditions like diabetes, obesity, and certain types of hair loss, such as alopecia.

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    1. Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics? Archives of dermatological research · 2015 · 60 citations
    2. PPAR-<i>γ</i> Agonists and Their Role in Primary Cicatricial Alopecia PPAR Research · 2017 · 38 citations
    3. Mechanism of PPAR&#x3B1; agonist in alopecia areata American Journal of Translational Research · 2025 · 1 citations
    4. Non-clinical safety evaluation and risk assessment to human of aleglitazar, a dual PPAR α/γ agonist, and its major human metabolite Regulatory toxicology and pharmacology · 2017 · 3 citations
    5. Functions of peroxisome proliferator‐activated receptors (PPAR) in skin homeostasis Lipids · 2004 · 46 citations
    6. Keratin 79 is a PPARA target that is highly expressed by liver damage Biochemical and biophysical research communications · 2023 · 1 citations
    7. Lichen Planopilaris Treated With a Peroxisome Proliferator–Activated Receptor γ Agonist Archives of dermatology · 2009 · 105 citations
    8. PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology Experimental Dermatology · 2019 · 24 citations
    9. Peroxisome proliferator-activated receptors-mediated diabetic wound healing regulates endothelial cells’ mitochondrial function via sonic hedgehog signaling Burns & Trauma · 2025 · 5 citations
    10. 0866 Role of transcriptional elongation in dermal fat development Journal of Investigative Dermatology · 2025
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